Korean J Intern Med.  2006 Mar;21(1):46-49. 10.3904/kjim.2006.21.1.46.

Epstein-Barr virus-associated Hodgkin's disease following renal transplantation

• Choi JH
• Ahn MJ
• Oh YH
• Han SW
• Kim HJ
• Lee YY
• Kim IS

• KMID: 1782252
• DOI: http://doi.org/10.3904/kjim.2006.21.1.46

Abstract

Post-transplant lymphoproliferative disorders (PTLD) have been recognized as a complication of immunosuppression and occur with a reported incidence of 1 to 8% of recipients receiving solid organ transplantation. PTLD are classified into two major categories, polymorphic and monomorphic PTLD. The majority of the monomorphic PTLD cases are non-Hodgkin's lymphoma of B-cell origin. Hodgkin's disease is not part of the typical spectrum of PTLD; however, it has been rarely reported. We describe a case of Hodgkin's disease following renal transplantation. A 41-year-old man developed right cervical lymphadenopathy following renal transplantation 116 months previously for chronic renal failure of unknown origin. He had been taking cyclosporine, mycophenolate mofetil and prednisone. A lymph node biopsy revealed mixed cellularity Hodgkin's disease. Immunohistochemical staining was positive for CD30 and EBV-latent membrane protein-1. No other site of disease was identified. The immunosuppressive agents were reduced (mycophenolate mofetil was discontinued, cyclosporine dose reduced from 200 mg to 150 mg and prednisone continued at 5 mg). After 2 cycles of ABVD followed by radiation therapy (3600 cGy), he achieved complete remission.

Keyword

Post-transplant lymphoproliferative disorder; Hodgkin's disease; Renal transplantation

MeSH Terms

Male
Lymphoproliferative Disorders/*chemically induced/immunology/virology
Kidney Transplantation/*adverse effects
Immunosuppressive Agents/*adverse effects
Humans
Hodgkin Disease/*etiology
*Herpesvirus 4, Human
Epstein-Barr Virus Infections/*complications
Adult