J Korean Med Sci.  2011 Feb;26(2):243-249. 10.3346/jkms.2011.26.2.243.

The Correlation between Thyrotropin and Dyslipidemia in a Population-based Study

• Lu L
• Wang B
• Shan Z
• Jiang F
• Teng X
• Chen Y
• Lai Y
• Wang J
• Xue H
• Wang S
• Li C
• Liu H
• Li N
• Yu J
• Shi L
• Hou X
• Xing Q
• Bai X
• Teng W

• KMID: 1782113
• DOI: http://doi.org/10.3346/jkms.2011.26.2.243

Abstract

This study investigated the relationship between serum thyrotrophin levels and dyslipidemia in subclinical hypothyroid and euthyroid subjects. A total of 110 subjects with subclinical hypothyroidism and 1,240 euthyroid subjects enrolled in this study. Patients with subclinical hypothyroidism had significantly lower high density lipoprotein cholesterol (HDL-C) levels than those who were euthyroid. The lipid profiles were each categorized and mean thyrotrophin levels were higher in subjects in the dyslipidemia subclasses than subjects in the normal subclasses. Thyrotrophin was positively associated with serum triglyceride and negatively associated with serum HDL-C in women. Thyrotrophin was also positively associated with total cholesterol (TC) in the overweight population along with TC and LDL-C in overweight women. In the euthyroid population, thyrotrophin was positively associated with TC in the overweight population. In conclusion, serum thyrotrophin was correlated with dyslipidemia in subclinical hypothyroid and euthyroid subjects; the correlation was independent of insulin sensitivity.

Keyword

Thyrotropin; Total Cholesterol; Cholesterol, LDL; Triglyceride; Cholesterol, HDL

MeSH Terms

Adolescent
Adult
Aged
Aged, 80 and over
Cholesterol/blood
Cholesterol, HDL/blood
Dyslipidemias/*blood
Female
Humans
Insulin Resistance
Lipids/blood
Male
Middle Aged
Thyrotropin/*blood
Triglycerides/blood
Young Adult

Figure

• 

  Fig. 1 Comparison of TSH by lipid profile categories after adjustment for age and sex in the overweight population. TG and TSH values were logarithmically transformed for statistical analyses. The *P = 0.027 was compared to normal LDL-C subclasses. TC, TG, and LDL-C subclasses were each categorized as normal, high normal, and high according to the treatment guidelines of dyslipidemia for adults in China in 2007; HDL-C subclasses were categorized as low, normal, and high.

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