J Korean Med Sci.  2005 Oct;20(5):848-852. 10.3346/jkms.2005.20.5.848.

Continuous Ambulatory Peritoneal Dialysis Patients Show High Prevalence of Carotid Artery Calcification which is Associated with a Higher Left Ventricular Mass Index

• Oh DJ

• KMID: 1781770
• DOI: http://doi.org/10.3346/jkms.2005.20.5.848

Abstract

This study examined intima-media thickness and arterial plaque occurrence in the carotid and brachial arteries in continuous ambulatory peritoneal dialysis (CAPD) patients. The study compared 25 CAPD patients with 25 normotensive age- and sex-matched controls. Intima-media thickness and presence of plaque in carotid and brachial artery were measured three times using high-resolution B-mode echocardiography. Left ventricular mass was calculated using the Penn Convection equation. Blood samples were obtained to assess levels of phosphorus, total calcium, serum albumin, C-reactive protein, and lipid profiles. Compared to the control group, CAPD patients had greater mean carotid and brachial intima-media thickness, and a higher proportion of subjects with calcified plaques. The left ventricular mass index was higher in CAPD patients with carotid artery calcified plaques compared to CAPD patients without carotid artery calcified plaques. CAPD patients with such plaque were significantly associated with diabetes mellitus, higher C-reactive protein levels and a lower 2-yr survival rate. The present study showed an high prevalence of carotid calcification in CAPD patients and those with such calcification had a greater incidence of diabetes mellitus, higher C-reactive protein levels and left ventricular mass index, and a lower survival rate.

Keyword

Peritoneal Dialysis, Continuous Ambulatory; Calcification; C-Reactive Protein; Carotid Arteries

MeSH Terms

Calcinosis/*mortality
Carotid Stenosis/*mortality
Comorbidity
Female
Humans
Hypertrophy, Left Ventricular/*mortality
Korea/epidemiology
Male
Middle Aged
Peritoneal Dialysis, Continuous Ambulatory/*statistics and numerical data
Prevalence
Prognosis
Research Support, Non-U.S. Gov't
Risk Assessment/*methods
Risk Factors
Severity of Illness Index
Statistics
Survival Analysis
Survival Rate

Figure

• 

  Fig. 1 Correlation between common carotid artery intima-media thickness and brachial artery intima-media thickness. CCA-IMT, common carotid artery intima-media thickness; BA-IMT, brachial artery intima-media thickness.

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