Ann Lab Med.  2013 Sep;33(5):371-374. 10.3343/alm.2013.33.5.371.

Two Cases of Near-Tetraploidy in Acute Leukemias of Ambiguous Lineage

• Kim BH
• Kim HR
• Lee MK
• Chi H

• KMID: 1781346
• DOI: http://doi.org/10.3343/alm.2013.33.5.371

Abstract

No abstract available.

MeSH Terms

Acute Disease
Aged
Aged, 80 and over
Bone Marrow Cells/cytology/metabolism/pathology
Cell Lineage
Humans
Immunophenotyping
Karyotyping
Leukemia/*genetics/metabolism/pathology
Male
*Tetraploidy

Figure

• 

  Fig. 1 Histomorphologic features of leukemic blasts from bone marrow aspirates and evidence of near-tetraploidy in 2 cases. (A) Leukemic blasts in case 1. Blasts were large and had high nuclear/cytoplasm ratios, irregular nuclei, a dispersed chromatin pattern, distinct nucleoli, and basophilic cytoplasm with pseudopods (Wright-Giemsa stain, ×1,000). (B) Karyotype of the abnormal clone in case 1. The arrows indicate additional or missing chromosomes from tetraploidy. The final karyotype was 89-93,XXYY,+X,-Y,-6,+7,-9,-14,-16,-18,-19,-20[cp6]/46,XY[14]. (C) Leukemic blasts in case 2. Blasts were large and had high nuclear/cytoplasm ratios, irregular nuclei, a dispersed chromatin pattern, and distinct nucleoli (Wright-Giemsa stain, ×1,000). (D) Karyotype of the abnormal clone in case 2. The arrows indicate additional or missing chromosomes from tetraploidy. The final karyotype was 93,XXYY,+13[8]/45,X,-Y[7]/46,XY[15].

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