Yonsei Med J.  2007 Apr;48(2):325-327. 10.3349/ymj.2007.48.2.325.

Photodynamic Therapy for Subretinal New Vessels

• Lee SC
• Bae JH
• Koh HJ
• Kim SS
• Kwon OW

• KMID: 1779539
• DOI: http://doi.org/10.3349/ymj.2007.48.2.325

Abstract

Photodynamic therapy (PDT) involves the induction of endothelial cell death or occlusion of blood vessels. On the basis of this mechanism of action, PDT is used in the treatment of predominant classic choroidal neovascularization (CNV), if the classic component is over 50%, and in myopic CNV. This study describes 2 cases of distinctive, abnormal, large, subretinal new vessels that are thought to have originated from the choroids. Diminishment of the new vessels was observed following treatment with PDT.

Keyword

Choroidal neovascularization; photodynamic therapy; retinal neovascularization

MeSH Terms

Retinal Vessels/drug effects/*pathology
Retinal Diseases/*drug therapy/pathology
*Photochemotherapy
Neovascularization, Pathologic/*drug therapy/pathology
Middle Aged
Male
Humans
Female
Angiography

Figure

• 

  Fig. 1 Case 1. (A) Indocyanine green angiogram (ICGA) reveals distinct atypical subretinal new vessel (large asterisk) and polypoid retinal hyper-fluorescent lesions (small asterisk) before photodynamic therapy (PDT). (B) ICGA taken 3 months after PDT shows no evidence of subretinal vessel and hyperfluorescent lesions.

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  Fig. 2 Case 2. (A) Indocyanine green angiogram (ICGA) reveals tadpole-shaped subretinal new vessels (asterisk) before photodynamic therapy (PDT). (B) ICGA after PDT show mild staining, indicating the obliteration of new vessels and replacement with fibrotic component. (C) Optical coherence tomography (OCT) before PDT shows hyper-reflectivity in the subretina from subretinal vascular complex. (D) OCT after PDT reveals localized hyper-reflective lesion due to healed fibrotic tissue.

Reference

1. Quaranta M, Mauget-Faysse M, Coscas G. Exudative idiopathic polypoidal choroidal vasculopathy and photodynamic therapy with verteporfin. Am J Ophthalmol. 2002. 134:277–280.

2. Lee SC, Song JH, Chung EJ, Kwon OW. Photodynamic therapy of subretinal neovascularization in radiation retinopathy. Eye. 2004. 18:745–746.