J Korean Med Sci.  2010 Nov;25(11):1672-1675. 10.3346/jkms.2010.25.11.1672.

Lymphoepithelioma-like Carcinoma of the Urinary Bladder

  • 1Department of Urology, Daegu Fatima Hospital, Daegu, Korea. aziru@lycos.co.kr
  • 2Department of Urology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea.
  • 3Department of Pathology, Daegu Fatima Hospital, Daegu, Korea.


A 78-yr-old woman presented with gross hematuria for 2 weeks. On cystoscopy, a frond-like mass was observed at the bladder trigone. Transurethral resection of bladder tumor was performed for the mass. Histopathological findings showed that 90% of lesions were lymphoepithelioma-like carcinoma (LELCA) and a few lesions were non-invasive transitional cell carcinoma. On microscopy, syncytial growth pattern and indistinct cytoplasmic borders were observed with the severe infiltration of lymphoid cells. The case was followed-up for 8 months without recurrence. This is the first report of a LELCA case in Korea.


Urinary Bladder; Lymphoepithelioma; Lymphoepithelioma-like carcinoma

MeSH Terms

Antigens, CD20/metabolism
Antigens, CD3/metabolism
Tomography, X-Ray Computed
Urinary Bladder Neoplasms/*diagnosis/pathology/surgery


  • Fig. 1 Frond-like mass with hemorrhage is detected in bladder.

  • Fig. 2 Mircoscopic finding. (A) Lymphoepithelioma-like carcinoma, syncytial pattern with prominent lymphocytic infiltrate. (B) Non-invasive transitional cell carcinoma with lymphoepithelioma-like carcinoma.

  • Fig. 3 Cytokerain staining. (A) Immunochemical staining with antibodies against cytokeratin 7 is positive. (B) Negative immunochemical staining with antibodies against cytokeratin 20.

  • Fig. 4 Immunochemical staining. (A) Positive staining with antibodies against CD3 shows abundant T-cells. (B) Positive staining with antibodies against CD20 shows abundant B-cells. (C) Leukocyte common antigen (LCA) stains lymphocytes (left). Non-invasive transitional cell carcinoma is negative for LCA (right).


1. Carbone A, Micheau C. Pitfalls in the microscopic diagnosis of undifferentiated carcinoma of nasopharyngeal type (lymphoephithelioma). Cancer. 1982. 50:1344–1351.
2. Tamas EF, Nielsen ME, Schoenberg MP, Epstein JI. Lymphoepithelioma-like carcinoma of the urinary tract: a clinicopathological study of 30 pure and mixed cases. Mod Pathol. 2007. 20:828–834.
3. Zukerberg LR, Harris NL, Young RH. Carcinoma of the urinary bladder simulating malignant lymphoma: A report of five cases. Am J Surg Pathol. 1991. 15:569–576.
4. Porcaro AB, Gilioli E, Migliorini F, Antoniolli SZ, Iannucci A, Comunale L. Primary lymphoepithelioma-like carcinoma of the urinary bladder: report of one case with review and update of the literature after a pooled analysis of 43 patients. Int Urol Nephrol. 2003. 35:99–106.
5. Cohen RJ, Stanley JC, Dawkins HJ. Lymphoepithelioma-like carcinoma of the renal pelvis. Pathology. 1999. 31:434–435.
6. Izquierdo-García FM, García-Díez F, Fernández I, Pérez-Rosado A, Sáez A, Suárez-Vilela D, Guerreiro-González R, Benéitez-Alvarez M. Lymphoepithelioma-like carcinoma of the bladder: three cases with clinicopathological and p53 protein expression study. Virchows Arch. 2004. 444:420–425.
7. Amin MB, Ro JY, Lee KM, Ordóñez NG, Dinney CP, Gulley ML, Ayala AG. Lymphoepithelioma-like carcinoma of the urinary bladder. Am J Surg Pathol. 1994. 18:466–473.
8. Siegelbaum MH, Edmonds P, Seidmon EJ. Use of immunohistochemistry for identification of primary lymphoma of the bladder. J Urol. 1986. 136:1074–1076.
9. Ward JN, Dong WF, Pitts WR Jr. Lymphoepithelioma-like carcinoma of the bladder. J Urol. 2002. 167:2523–2524.
10. Kang DK, Chung HS, Park CM, Kim HK, Park JY, Kang GH, Ro JY. Multiple oragn involvement of lymphoepithelioma-like carcinoma in the kidney and the ureter. Korean J Urol. 2003. 44:297–299.
11. Gulley ML, Amin MB, Nicholls JM, Banks PM, Ayala AG, Srigley JR, Eagan PA, Ro JY. Epstein-Barr virus is detected in undifferentiated nasopharyngeal carcinoma but not in lymphoepithelioma-like carcinoma of the urinary bladder. Hum Pathol. 1995. 26:1207–1214.
12. Holmäng S, Borghede G, Johansson SL. Bladder carcinoma with lymphoepithelioma-like differentiation: a report of 9 cases. J Urol. 1998. 159:779–782.
13. Dinney CP, Ro JY, Babaian RJ, Johnson DE. Lymphoepithelioma of the bladder: a clinicopathological study of 3 cases. J Urol. 1993. 149:840–841.
14. Kuten A, Cohen Y, Lavie R, Dale J, Ben Arush MB, Goldberg H, Stein M. Update on nasopharyngeal carcinoma in northern Israel. Strahlenther Onkol. 1994. 170:565–570.
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