J Korean Med Sci.  2010 Nov;25(11):1672-1675. 10.3346/jkms.2010.25.11.1672.

Lymphoepithelioma-like Carcinoma of the Urinary Bladder

Affiliations
  • 1Department of Urology, Daegu Fatima Hospital, Daegu, Korea. aziru@lycos.co.kr
  • 2Department of Urology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea.
  • 3Department of Pathology, Daegu Fatima Hospital, Daegu, Korea.

Abstract

A 78-yr-old woman presented with gross hematuria for 2 weeks. On cystoscopy, a frond-like mass was observed at the bladder trigone. Transurethral resection of bladder tumor was performed for the mass. Histopathological findings showed that 90% of lesions were lymphoepithelioma-like carcinoma (LELCA) and a few lesions were non-invasive transitional cell carcinoma. On microscopy, syncytial growth pattern and indistinct cytoplasmic borders were observed with the severe infiltration of lymphoid cells. The case was followed-up for 8 months without recurrence. This is the first report of a LELCA case in Korea.

Keyword

Urinary Bladder; Lymphoepithelioma; Lymphoepithelioma-like carcinoma

MeSH Terms

Aged
Antigens, CD20/metabolism
Antigens, CD3/metabolism
B-Lymphocytes/immunology/metabolism
Carcinoma/*diagnosis/pathology/surgery
Female
Hematuria/etiology
Humans
Keratin-20/metabolism
Keratin-7/metabolism
T-Lymphocytes/immunology/metabolism
Tomography, X-Ray Computed
Urinary Bladder Neoplasms/*diagnosis/pathology/surgery

Figure

  • Fig. 1 Frond-like mass with hemorrhage is detected in bladder.

  • Fig. 2 Mircoscopic finding. (A) Lymphoepithelioma-like carcinoma, syncytial pattern with prominent lymphocytic infiltrate. (B) Non-invasive transitional cell carcinoma with lymphoepithelioma-like carcinoma.

  • Fig. 3 Cytokerain staining. (A) Immunochemical staining with antibodies against cytokeratin 7 is positive. (B) Negative immunochemical staining with antibodies against cytokeratin 20.

  • Fig. 4 Immunochemical staining. (A) Positive staining with antibodies against CD3 shows abundant T-cells. (B) Positive staining with antibodies against CD20 shows abundant B-cells. (C) Leukocyte common antigen (LCA) stains lymphocytes (left). Non-invasive transitional cell carcinoma is negative for LCA (right).


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