J Korean Med Sci.  2010 Mar;25(3):429-434. 10.3346/jkms.2010.25.3.429.

Cefotetan versus Conventional Triple Antibiotic Prophylaxis in Elective Colorectal Cancer Surgery

• Jeong WK
• Park JW
• Lim SB
• Choi HS
• Jeong SY

• KMID: 1778039
• DOI: http://doi.org/10.3346/jkms.2010.25.3.429

Abstract

This study examined infectious outcomes in elective colorectal cancer surgery between cefotetan alone or conventional triple antibiotics. From January to December 2007, 461 consecutive primary colorectal cancer patients underwent elective surgery. Group A contained 225 patients who received conventional triple antibiotics (cephalosporin, aminoglycoside and metronidazole) for prophylaxis, and group B contained 236 patients who received cefotetan alone for prophylaxis. Treatment failure was defined as the presence of postoperative infection including surgical-site infection (SSI), anastomotic leakage, and pneumonia or urinary tract infection. The two groups were similar in terms of demographics, American Society of Anesthesiologists (ASA) score, tumour location, stage, surgical approach (conventional open vs. laparoscopy-assisted), and type of operation. The treatment failure rates were 3.1% in Group A and 3.4% in Group B (absolute difference, -0.3%; 95% confidence interval [CI], 0.39 to 3.07, P=0.866), with SSI being the most common reason for failure in both groups (2.7% in Group A and 3.0% in Group B [absolute difference, -0.3%; 95% CI, 0.37 to 3.37, P=0.846]). Cefotetan alone is as effective as triple antibiotics for prophylaxis in primary colorectal cancer patients undergoing elective surgery.

Keyword

Antibiotic Prophylaxis; Colorectal Neoplasms; Surgical Wound Infection; Cefotetan

MeSH Terms

Adolescent
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents/*therapeutic use
*Antibiotic Prophylaxis
Cefotetan/*therapeutic use
Colorectal Neoplasms/*surgery
Drug Therapy, Combination
Humans
Male
Middle Aged
Postoperative Complications/*prevention & control
Surgical Wound Infection/*prevention & control
Treatment Failure
Treatment Outcome
Young Adult
Anti-Bacterial Agents
Cefotetan

Figure

• 

  Fig. 1 Laboratory parameters. *P<0.05. Preop, preoperative; POD1, postoperative day 1; POD5, postoperative day 5.

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