J Korean Med Sci.  2011 Aug;26(8):1093-1098. 10.3346/jkms.2011.26.8.1093.

Vitamin K Supplement Along with Vitamin D and Calcium Reduced Serum Concentration of Undercarboxylated Osteocalcin While Increasing Bone Mineral Density in Korean Postmenopausal Women over Sixty-Years-Old

• Je SH
• Joo NS
• Choi BH
• Kim KM
• Kim BT
• Park SB
• Cho DY
• Kim KN
• Lee DJ

• KMID: 1777850
• DOI: http://doi.org/10.3346/jkms.2011.26.8.1093

Abstract

There are inconsistent findings on the effects of vitamin K on bone mineral density (BMD) and undercarboxylated osteocalcin (UcOC). The present intervention study evaluated the effect in subjects over 60-yr-old. The vitamin K group (vitamin K + vitamin D + calcium supplement; 15 mg of vitamin K2 [menatetrenone] three times daily, 400 IU of vitamin D once a day, and 315 mg of calcium twice daily) and the control group (vitamin D + calcium supplement) were randomly assigned. During the six months of treatment, seventy eight women participated (38 in the vitamin K group and 40 in the control group) and 45 women completed the study. The baseline characteristics of study participants did not differ between the vitamin K and the control groups. In a per protocol analysis after 6 months, L3 bone mineral density has increased statistically significantly in the vitamin K group compared to the control group (0.01 +/- 0.03 g/cm2 vs -0.008 +/- 0.04 g/cm2, P = 0.049). UcOC concentration was also significantly decreased in the vitamin K group (-1.6 +/- 1.6 ng/dL vs -0.4 +/- 1.1 ng/dL, P = 0.008). In conclusion, addition of vitamin K to vitamin D and calcium supplements in the postmenopausal Korean women increase the L3 BMD and reduce the UcOC concentration.

Keyword

Vitamin K; Undercarboxylated osteocalcin; Bone Mineral Density; Korean Women

MeSH Terms

Aged
Bone Density/*drug effects
Calcium/*administration & dosage
Dietary Supplements
Female
Humans
Middle Aged
Osteocalcin/*blood
Postmenopause
Republic of Korea
Vitamin D/*administration & dosage
Vitamin K/*administration & dosage

Figure

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  Fig. 1 Screening, randomization and follow up for study subjects.

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