J Korean Med Sci.  2011 Aug;26(8):1061-1067. 10.3346/jkms.2011.26.8.1061.

Characteristics of Sodium Sensitivity in Korean Populations

• Shin SJ
• Lim CY
• Rhee MY
• Oh SW
• Na SH
• Park Y
• Kim CI
• Kim SY
• Kim JW
• Park HK

• KMID: 1777845
• DOI: http://doi.org/10.3346/jkms.2011.26.8.1061

Abstract

Sodium sensitivity (SS) is a variable response of blood pressure (BP) to changes in sodium intake. The present study evaluated the existence and the characteristics of subjects with SS in Koreans. One hundred one subjects with (n = 31, 57.7 +/- 9.8 yr) or without hypertension (n = 70, 40.8 +/- 16.5 yr) were given a low-sodium dietary approache to stop hypertension (DASH) diet (LSD) for 7 days and a high-sodium DASH diet (HSD) for the following 7 days. The prevalence of SS in the present study population was 27.7% (17.6% in the non-hypertensive subjects and 51.6% in the hypertensive subjects). Analysis of the non-hypertensive subjects showed that systolic BP, diastolic BP, and mean arterial pressure at baseline and after HSD were higher in the subjects with SS than the subjects without SS, and there were no differences after LSD. In the hypertensive subjects, there was no difference in the BP at baseline and after HSD whether or not the subjects had SS. However, the systolic BP of hypertensive subjects with SS was lower than hypertensive subjects without SS after LSD. In the present study population, subjects with SS have distinctive BP features unlike to subjects without SS.

Keyword

Hypertension; Sodium Sensitivity; DASH Diet

MeSH Terms

Adult
Aged
Blood Chemical Analysis
Blood Pressure/drug effects/physiology
Diet, Sodium-Restricted/methods
Humans
Hypertension/*diet therapy/etiology/prevention & control
Middle Aged
Republic of Korea
Sodium, Dietary/*adverse effects
Urinalysis
Young Adult

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