J Korean Med Sci.  2013 Oct;28(10):1522-1528. 10.3346/jkms.2013.28.10.1522.

Improvement of Dementia Screening Accuracy of Mini-Mental State Examination by Education-Adjustment and Supplementation of Frontal Assessment Battery Performance

• Kim JW
• Lee DY
• Seo EH
• Sohn BK
• Park SY
• Choo IH
• Youn JC
• Jhoo JH
• Kim KW
• Woo JI

• KMID: 1777692
• DOI: http://doi.org/10.3346/jkms.2013.28.10.1522

Abstract

This study aimed to investigate whether the demographic variable-adjustment and supplementation of Frontal Assessment Battery (FAB) score can improve the screening ability of Mini-Mental State Examination (MMSE) for dementia and its subtypes. Five hundred forty-one non-demented comparison (NC) and 474 dementia (320 Alzheimer's disease [AD]; 139 non-Alzheimer's disease dementia [NAD]; and 15 mixed AD-NAD dementia) individuals living in the community were included. Education-adjusted MMSE (MMSE-edu) score showed significantly better screening accuracy for overall dementia, AD, and NAD than MMSE raw score. FAB-supplemented MMSE (MMSE-FAB) score had significantly better screening ability for NAD, but not for overall dementia and AD, than MMSE raw score alone. Additional supplementation of FAB to MMSE-edu further increased the ability for overall dementia or NAD screening, but not for AD screening. Further education adjustment of MMSE-FAB also improved its ability for overall dementia, AD, and NAD screening. These results strongly support the usefulness of education-adjustment and supplementation of frontal function assessment to improve screening performance of MMSE for dementia and its subtypes, NAD in particular.

Keyword

Mini-Mental State Examination; Frontal Assessment Battery; Education; Dementia; Screening Accuracy

MeSH Terms

Aged
Aged, 80 and over
Alzheimer Disease/complications/diagnosis
Area Under Curve
Dementia/complications/*diagnosis
Demography
Diagnosis, Differential
Female
Humans
Male
Middle Aged
Neuropsychological Tests
ROC Curve

Figure

• 

  Fig. 1 Receiver operating characteristic curves of Mini-Mental State Examination (MMSE), Frontal Assessment Battery (FAB), education-adjusted MMSE (MMSE-edu), FAB-supplemented MMSE (MMSE-FAB), and education-adjusted MMSE-FAB (MMSE-FAB-edu) in screening for (A) overall dementia, (B) Alzheimer's disease, and (C) non-Alzheimer's disease dementia.

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