J Korean Med Sci.  2013 Jul;28(7):1083-1088. 10.3346/jkms.2013.28.7.1083.

Recent Trends (1991-2010) of Metastatic Skin Cancers in Korea

• Bang CH
• Bae JM
• Kim HS
• Kim GM
• Yu DS
• Park HJ
• Oh ST
• Kang H
• Park CJ
• Lee JD
• Lee JY
• Kim HO
• Park YM

• KMID: 1777507
• DOI: http://doi.org/10.3346/jkms.2013.28.7.1083

Abstract

The incidence of overall cancer has increased over time. The incidence of top-ranking cancers has changed in the 1990s and the 2000s. However, few studies have evaluated the trends in metastatic skin cancers during this period. We evaluated the recent trends in incidence, peak age and location of metastatic skin cancers from 1991 to 2010. This 20-yr survey was divided into two decades to determine the trends by comparing the statistics. Out of 694,466 outpatients (1991-2010), 174 (0.025%) were diagnosed with metastatic skin cancer. The incidence of metastatic skin cancer increased significantly from 20.64 per 100,000 outpatients in the 1990s to 28.70 per 100,000 outpatients in the 2000s (P = 0.030). The peak age of skin metastasis shifted from the 40s to the 50s in women, and from the 50s to the 60s in men. The percentage of metastatic skin cancers originating from intra-abdominal organs increased from 10% in the 1990s to 23.1% in the 2000s (P = 0.027). The percentage of metastatic skin cancers located on the abdomen increased from 7.1% in the 1990s to 15.4% in the 2000s (P = 0.011). The higher proportion of metastatic skin cancers located on the abdomen may be related to the increase in skin metastases from intra-abdominal organs.

Keyword

Metastatic Skin Cancers Incidence; Abdomen; Intra-Abdominal Organs

MeSH Terms

Adult
Age Distribution
Aged
Aged, 80 and over
Female
Humans
Incidence
Male
Middle Aged
Registries
Republic of Korea/epidemiology
Skin Neoplasms/*epidemiology/*secondary
Young Adult

Figure

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  Fig. 1 The incidence of internal organ cancer per 100,000 Koreans.

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  Fig. 2 The number of metastatic skin cancer patients during 1991-2010 (A) The number of metastatic skin cancer patients and the comparison of the incidence of metastatic skin cancers between the 1990s and the 2000s in the total dermatologic outpatient population. (B) The number of metastatic skin cancer patients by year with increasing slope with exponential pattern (P = 0.001 by Poisson regression).

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  Fig. 3 The age and sex distrubution of the metastatic skin cancer patients in the 1990s and the 2000s.

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  Fig. 4 The proportion of the individual primary cancer by pie chart and the proportion of the intra-abdominal origin cancer by bar graph in (A) the 1990s and (B) the 2000s.

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  Fig. 5 The proportion of metastatic cancers at each location in the 1990s and the 2000s.

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