Korean J Gastroenterol.  2010 Jan;55(1):26-32. 10.4166/kjg.2010.55.1.26.

Oxaliplatin and Leucovorin Plus Fluorouracil Versus Irinotecan and Leucovorin Plus Fluorouracil Combination Chemotherapy as a First-line Treatment in Patients with Metastatic or Recurred Gastric Adenocarcinoma

• Kang SH
• Kim JI
• Moon HS
• Kim SH
• Sung JK
• Lee BS
• Jeong HY

• KMID: 1775923
• DOI: http://doi.org/10.4166/kjg.2010.55.1.26

Abstract

BACKGROUND/AIMS
We performed retrospective study in order to compare oxaliplatin, leucovorin, and fluorouracil (FOLFOX) versus irinotecan, leucovorin, and fluorouracil (FOLFIRI) in recurred or metastatic gastric adenocarcinoma.
METHODS
We investigated 56 patients who were diagnosed with recurred or metastatic gastric adenocarcinoma in a single center during march, 2003 to march, 2008. The patients received either FOLFOX or FOLFIRI chemotherapy.
RESULTS
There were no significant difference between the Oxaliplatin group (30 patients) and Irinotecan group (26 patients) in sex, age, and ECOG performance (p>0.05). Oxaliplatin group showed 1 case of CR (3.3%) and 12 cases of PR (40%), making the response rate 43.3%. Irinotecan group showed CR in 2 cases (7.7%) and PR in 10 cases (38.5%), making the response rate 46.2%. The median value of time to progression was 4 months in the oxlaplatin group and 4.5 months in the irinotecan group. The overall survival showed no significant difference (p=0.784), with the irinotecan group (9.7 months) being slightly longer than the Oxaliplatin group (8.3 months). Grade 3/4 neutropenia occurred similarly in both groups (4 cases in the oxalplatin group, 9 in the irinotecan group).
CONCLUSIONS
Both combination treatment can be used safely and effectively in recurred or metastatic gastric adenocarcinoma.

Keyword

Gastric adenocarcinoma; Oxaliplatin; Irinotecan

MeSH Terms

Adenocarcinoma/*drug therapy/mortality/secondary
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Camptothecin/analogs & derivatives/therapeutic use
Female
Fluorouracil/therapeutic use
Humans
Leucovorin/therapeutic use
Male
Middle Aged
Neoplasm Recurrence, Local/drug therapy
Organoplatinum Compounds/therapeutic use
Recurrence
Retrospective Studies
Stomach Neoplasms/*drug therapy/mortality
Survival Analysis

Figure

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  Fig. 1. Time to progression. There was no statistical difference between two groups.

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  Fig. 2. Overall survival. There was no statistical difference between two groups.

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