Gut Liver.  2014 Mar;8(2):117-130.

Population Screening for Colorectal Cancer Means Getting FIT: The Past, Present, and Future of Colorectal Cancer Screening Using the Fecal Immunochemical Test for Hemoglobin (FIT)

Affiliations
  • 1Division of Gastroenterology, University of California San Francisco School of Medicine, San Francisco, CA, USA. jallison@medsfgh.ucsf.edu
  • 2Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
  • 3Centre for Research into Cancer Prevention and Screening, University of Dundee School of Medicine, Dundee, Scotland.
  • 4NHS Bowel Cancer Screening Southern Programme Hub, Royal Surrey County Hospital and University of Surrey, Guildford, UK.
  • 5Flinders Centre for Innovation in Cancer, Flinders University, Bedford Park SA, Australia.

Abstract

Fecal immunochemical tests for hemoglobin (FIT) are changing the manner in which colorectal cancer (CRC) is screened. Although these tests are being performed worldwide, why is this test different from its predecessors? What evidence supports its adoption? How can this evidence best be used? This review addresses these questions and provides an understanding of FIT theory and practices to expedite international efforts to implement the use of FIT in CRC screening.

Keyword

Population screening; Colorectal cancer; Fecal immunochemical test for hemoglobin; Colorectal cancer screening

MeSH Terms

Colorectal Neoplasms/*diagnosis
Early Detection of Cancer/methods/trends
Feces/*chemistry
Forecasting
Global Health
Hemoglobins/*analysis
Humans
Immunochemistry
Mass Screening/methods/trends
Occult Blood
Sensitivity and Specificity
Hemoglobins
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