J Lipid Atheroscler.  2014 Dec;3(2):97-104. 10.12997/jla.2014.3.2.97.

Comparing High-Intensity Versus Low-to Moderate-Intensity Statin Therapy in Korean Patients with Acute Myocardial Infarction

• Kim M
• Kim HK
• Ahn Y
• Park H
• Jeong MH
• Cho JG
• Park JC
• Kim YJ
• Cho MC
• Kim CJ
• Korea Acute Myocardial Infarction Registry Investigators

• KMID: 1773888
• DOI: http://doi.org/10.12997/jla.2014.3.2.97

Abstract

OBJECTIVE
The aim of this study is to compare the clinical benefits between high-intensity and low-to moderate-intensity statin therapy in patients with acute myocardial infarction (AMI).
METHODS
A total of 1,230 patients in the Korea AMI Registry (KAMIR) were enrolled. Patients were divided into two groups according to the dosage of statin for the secondary prevention after AMI. The primary endpoint was composite of major adverse cardiac events (MACEs) including cardiac death, non-fatal MI, repeat revascularization during the 12 months of clinical follow-up. RESULT: The primary endpoint occurred in 101 patients (11.3%) from the low-to moderate-intensity statin group and 45 patients (13.4%) from the high-intensity statin group. The cumulative incidence of MACEs during 12-month follow-up was not significantly different between the two groups (p=0.323). After multi-variate analysis, MACEs-free survival rate was not significantly different between the two groups.
CONCLUSION
High-intensity statin therapy did not show additional clinical benefit over low-to moderate-intensity statin therapy after AMI.

Keyword

Myocardial infarction; Statin; Secondary prevention

MeSH Terms

Death
Follow-Up Studies
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors*
Incidence
Korea
Myocardial Infarction*
Secondary Prevention
Survival Rate

Figure

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  Fig. 1 Kaplan-Meier curve for 12-month major adverse cardiac event-free survival rates between low-intermediate intensity statin group and high intensity statin group.

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