Korean Circ J.  2013 Feb;43(2):82-86. 10.4070/kcj.2013.43.2.82.

Evaluation of Cardiac Functions with Tissue Doppler Imaging in Prediabetic Subjects

• Kanat M
• Vardi S
• Arinc H
• Gunduz H
• Erdem A
• Karagoz Y

• KMID: 1769642
• DOI: http://doi.org/10.4070/kcj.2013.43.2.82

Abstract

BACKGROUND AND OBJECTIVES
The aim of the present study was to evaluate left ventricle systolic and diastolic function, using tissue Doppler echocardiography (TDE), in relation to blood glucose status in prediabetic patients who had no evidence of heart disease by conventional echocardiography (CE).
SUBJECTS AND METHODS
We included 60 patients (30 female, 30 male) and 20 healthy controls (10 male, 10 female). All participants were randomised into four groups according to their oral glucose tolerance test. Group-I consisted of those patients who had only impaired fasting glucose (IFG). group-II consisted of patients who had only impaired glucose tolerance (IGT) and group-III consisted of patients who had both IFG and IGT, that is so-called combined glucose intolerance. Group-IV included the healthy controls. All subjects underwent both CE and TDE.
RESULTS
No significant differences were found among the four groups in terms of CE. There was no significant difference between group-IV and group-I with respect to the early peak diastolic velocity (Ea) of medial mitral annulus (11.65+/-0.66 vs. 9.72+/-1.58, p>0.05), whereas a statistically significant difference was found between group-IV and group-II (11.65+/-0.66 vs. 9.06+/-1.07, p<0.001) and between group-IV and group-III (11.65+/-0.66 vs. 9.74+/-1.09, p<0.05).
CONCLUSION
Diastolic myocardial dysfunction in prediabetic patients may be identified by quantitative TDE before the appearance of CE indices of myocardial dysfunction.

Keyword

Type 2 diabetes mellitus; Diabetic cardiomyopathies; Tissue Doppler imaging; Glucose intolerance

MeSH Terms

Blood Glucose
Diabetes Mellitus, Type 2
Diabetic Cardiomyopathies
Echocardiography
Echocardiography, Doppler
Fasting
Female
Glucose
Glucose Intolerance
Glucose Tolerance Test
Heart Diseases
Heart Ventricles
Humans
Male
Blood Glucose
Glucose

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