Korean J Gastroenterol.  2008 May;51(5):285-290.

Efficacy of Levofloxacin-based Triple Therapy as Second-lineHelicobacter pylori Eradication

• Jung HS
• Shim KN
• Baik SJ
• Na YJ
• Kang MJ
• Jung JM
• Ha CY
• Jung SA
• Yoo K

Abstract

BACKROUND/AIMS: Bismuth-based quadruple therapy for second-line eradication treatment achieves the eradication rate ranging from 70% to 81% due to antimicrobial resistance and poor compliance. The aim of this study was to compare the eradication rate of levofloxacin-based triple therapy with that of bismuth-based quadruple therapy in second-line Helicobacter pylori (H. pylori) eradication therapy.
METHODS
Seventy-six outpatients with persistent H. pylori infection after first-line triple therapy were enrolled in this prospective randomized trial. The subjects were randomized to receive levofloxacin 300 mg, amoxicillin 1 g, and pantoprazole 20 mg, given twice daily for 7 days (LAP group), or metronidazole 500 mg twice, tetracycline 500 mg four times, and pantoprazole 20 mg twice, bismuth subcitrate 600 mg twice daily for 7 days (MTPB group). Eradication was confirmed with 13C-urea breath test or rapid urease test 4 weeks after the cessation of therapy.
RESULTS
Among Seventy-six patients initially included, eleven were lost during follow-up. The eradication rates, expressed as intention to treat (ITT) and per protocol (PP) analyses, were 51.6% and 53.3% in the LAP group, and 48.9% and 62.9% in the MTPB group, respectively. There was no significant difference in H. pylori eradication rates between the two groups (p=0.815 by ITT, p=0.437 by PP). LAP regimen was better tolerated than MTPB regimen with lower incidence of side effects (10.0% versus 31.4%, p=0.03).
CONCLUSIONS
H. pylori eradication rates of levofloxacin-based triple therapy and bismuth-based quadruple therapy were not significantly different in second-line H. pylori eradication therapy, and low incidence of side effects was observed in levofloxacin-based triple therapy.

Keyword

Helicobacter pylori; Eradication; Levofloxacin

MeSH Terms

2-Pyridinylmethylsulfinylbenzimidazoles/administration & dosage
Adult
Antacids/administration & dosage
Anti-Bacterial Agents/*administration & dosage
Anti-Ulcer Agents/administration & dosage
Data Interpretation, Statistical
Drug Therapy, Combination
Female
Helicobacter Infections/*drug therapy/microbiology
*Helicobacter pylori
Humans
Male
Middle Aged
Ofloxacin/*administration & dosage
Organometallic Compounds/administration & dosage
Time Factors
Treatment Outcome