Korean J Otolaryngol-Head Neck Surg.
2001 Mar;44(3):246-250.
Comparison of early tissue reactions between Plastipore and Polycel in rat middle ear
- Affiliations
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- 1Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Hallym University, Seoul, Korea.
Abstract
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BACKGROUND & OBJECTIVES: There has been only a few reports of animal investigation of the fate of otologic polymer. This study was designed for comparing the early tissue reaction of Plastipore and Polycel that have been most commonly used.
MATERIALS & METHODS: Plastipore and Polycel were inserted into middle ear of Sprague Dawley rats. After 1, 2 and 4 weeks, the temporal bones were removed and tissue reactions were observed with Hematoxillin-Eosin stain.
RESULTS
More neutrophils were infiltrated along the septae of the Plastipore compared with Polycel after 1 week and 2 weeks. ibrotic changes were found on the surface of Plastipores. After 4 weeks, the tissue reaction of Polycel shows weaker than the Plastipore. It showed that the Plastipore had more pronounced and rapid tissue reactions with a thick fibrous encapsulation around it.
CONCLUSION
Plastipore could have relatively worse biocompatibility compared with Polycel.
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