J Korean Surg Soc.  2010 Apr;78(4):207-212. 10.4174/jkss.2010.78.4.207.

Risk Factors for Lymph Node Metastasis in Patients with Submucosal Invasive Colorectal Carcinoma

• Sung HY
• Kang WK
• Kim SW
• Nam KW
• Jung CK
• Chang JH
• Cho YK
• Park JM
• Lee IS
• Lee JI
• Oh ST
• Choi MG
• Chung IS

• KMID: 1750731
• DOI: http://doi.org/10.4174/jkss.2010.78.4.207

Abstract

PURPOSE
This study was designed to determine the risk factors of lymph node (LN) metastasis in patients with submucosal invasive colorectal cancer (SICC).
METHODS
Between January 1998 and January 2009, we reviewed patients who had undergone radical colon resection with LN dissection for SICC.
RESULTS
There were 36 males and 40 females (mean age, 61.1 years; range, 35~86 years). In the univariate analysis, the risk of LN metastasis was related to the depth (absolute and relative), lymphovascular invasion, tumor budding, and tumor differentiation (P<0.05). The relative depth by Kudo classification and lymphovascular invasion were significant predictors of LN metastasis both in univariate and multivariate analysis. In SICC with an absolute depth <1,800 microm, no LN metastasis was detected. Regardless of the size of the SICC, tumors that invaded within the sm2 layer and had no lymphovascular invasion had no LN metastasis.
CONCLUSION
In the SICC, lymphovascular invasion and depth of submucosal invasion are strong predictors of LN metastasis. If deep invasion exceeds sm2 and positive lymphovascular invasion exists in the resected specimen, additional colectomy with LN dissection appears to be necessary.

Keyword

Submucosal invasive colorectal cancer; Lymph node metastasis; Lymphovascular invasion; Endoscopic mucosal dissection

MeSH Terms

Colectomy
Colon
Colorectal Neoplasms
Female
Humans
Lymph Nodes
Male
Multivariate Analysis
Neoplasm Metastasis
Risk Factors

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