Korean J Clin Neurophysiol.  2014 Dec;16(2):77-80. 10.14253/kjcn.2014.16.2.77.

Recurrent Herpes Simplex Virus Type-2 Meningitis in an Adolescent Girl

• Hwang Y
• Kim Y
• Park H
• Park H
• Cho J
• Park D
• Cho K

• KMID: 1737969
• DOI: http://doi.org/10.14253/kjcn.2014.16.2.77

Abstract

Herpes simplex virus type 2 (HSV2) meningitis primarily develops during or following a primary genital HSV2 infection that was acquired from sexual contact or through the birth canal during delivery from mother. We describe a 15 year old virgin without history of previous herpes simplex infection who developed 2 episodes of HSV2 meningitis. Although recurrent meningitis due to HSV is primarily seen in young or sexually active adults. HSV2 meningitis should be in the differential diagnosis of recurrent meningitis in adolescent patients.

Keyword

Recurrent meningitis; Herpes simplex meningitis; Mollaret's meningitis

MeSH Terms

Adolescent*
Adult
Diagnosis, Differential
Female
Herpes Simplex
Herpesvirus 2, Human
Humans
Meningitis*
Mothers
Parturition
Simplexvirus*

Figure

• 

  Figure 1. Agarose gel electrophoresis showing multiplex polymerase chain reaction amplified products from the ser-ebrospinal fluid. Lane 1 shows molecular weight markers with target sizes in base pairs. Lane 2 and 3 show the patient’s positive results for HSV-2 in two consecutive episodes. Lane 4 is a distilled water negative control. IC; internal control, CMV; cytomegalovirus, HHV6; human herpes vi rus 6, EBV; Epstein-Barr virus, HSV; herpes simplex virus, VZV; varicella-zoster virus.

Reference

1.Shalabi M., Whitley RJ. Recurrent benign lymphocytic meningitis. Clin Infect Dis. 2006. 43:1194–1197.

2.Davis LE., Guerre J., Gerstein WH. Recurrent herpes simplex virus type 2 meningitis in elderly persons. Arch Neurol. 2010. 67:759–760.

3.Miller S., Mateen FJ., Aksamit AJ Jr. Herpes simplex virus 2 meningitis: a retrospective cohort study. J Neurovirol. 2013. 19:166–171.

4.Steiner I., Benninger F. Update on herpes virus infections of nervous system. Curr Neurol Neurosci Rep. 2013. 13:414.

5.Abu Khattab M., Al Soub H., Al Masalamani M., Al Khuwaiter J., El Deeb Y. Herpes simplex virus type 2 (Mollaret's) meningitis: a case report. Int J Infect Dis. 2009 Mar 28. [Epub]. Doi: 10.1016/jijd.2009.01.003.

6.Kim SY., Yang EJ., Nam SU. A Case of Mollaret Meningitis. J Korean Pediatr Soc. 1999. 42:122–127.

7.Kim MK., Sung TJ., Kim JK., Yang EJ., Hong YJ. A Case Mollaret Meningitis. Korean J Pediatr Infect Dis. 2000. 7:159–164.

8.Benedetti J., Corey L., Ashley R. Recurrence rates in genital herpes after symptomatic first-episode infection. Ann Intern Med. 1994. 121:847–854.

9.Jensenius M., Myrvang B., Størvold G., Bucher A., Hellum KB., Bruu AL. Herpes simplex virus type 2 DNA detected in cerebrospinal fluid of 9 patients with Mollaret's meningitis. Acta Neurol Scand. 1998. 98:209–212.

10.Forsgren M., Sköldenberg B., Aurelius E., Gille E. Neurologic morbidity after herpes simplex virus type 2 meningitis: a retrospective study of 40 patients. Scandinavian journal of infectious diseases. 2002. 34:278–283.