J Vet Sci.  2014 Mar;15(1):117-123. 10.4142/jvs.2014.15.1.117.

Photodynamic hyperthermal chemotherapy with indocyanine green: a novel cancer therapy for 16 cases of malignant soft tissue sarcoma

  • 1The United Graduated Veterinary Science, Yamaguchi University, Yamaguchi 753-8515, Japan.
  • 2Department of Veterinary Diagnostic Imaging, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan.
  • 3Department of Veterinary Surgery, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan. yokamoto@muses.tottori-u.ac.jp
  • 4Department of Veterinary Neurology and Oncology, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan.
  • 5Aino Animal Hospital, Shizuoka 437-0023, Japan.
  • 6Tokyo Animal Medical Center, Tokyo 167-0054, Japan.
  • 7Takayama Pet Clinic, Osaka 546-0003, Japan.
  • 8Tokyo Iken Co. Ltd. Tokyo 206-0802, Japan.


Sixteen cases of malignant soft tissue sarcoma (STS; 10 canines and six felines) were treated with a novel triple therapy that combined photodynamic therapy, hyperthermia using indocyanine green with a broadband light source, and local chemotherapy after surgical tumor resection. This triple therapy was called photodynamic hyperthermal chemotherapy (PHCT). In all cases, the surgical margin was insufficient. In one feline case, PHCT was performed without surgical resection. PHCT was performed over an interval of 1 to 2 weeks and was repeated three to 21 times. No severe side effects, including severe skin burns, necrosis, or skin suture rupture, were observed in any of the animals. No disease recurrence was observed in seven out of 10 (70.0%) dogs and three out of six (50.0%) cats over the follow-up periods ranging from 238 to 1901 days. These results suggest that PHCT decreases the risk of STS recurrence. PHCT should therefore be considered an adjuvant therapy for treating companion animals with STS in veterinary medicine.


cancer; chemotherapy; hyperthermia; PDT; soft tissue sarcoma

MeSH Terms

Antineoplastic Agents/*therapeutic use
Cat Diseases/drug therapy/surgery/*therapy
Combined Modality Therapy/veterinary
Dog Diseases/drug therapy/surgery/*therapy
Hyperthermia, Induced/veterinary
Indocyanine Green/*therapeutic use
Photosensitizing Agents/*therapeutic use
Sarcoma/drug therapy/surgery/therapy/*veterinary
Antineoplastic Agents
Indocyanine Green
Photosensitizing Agents
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