J Vet Sci.  2014 Mar;15(1):117-123. 10.4142/jvs.2014.15.1.117.

Photodynamic hyperthermal chemotherapy with indocyanine green: a novel cancer therapy for 16 cases of malignant soft tissue sarcoma

• Onoyama M
• Tsuka T
• Imagawa T
• Osaki T
• Minami S
• Azuma K
• Kawashima
• Ishi H
• Takayama T
• Ogawa N
• Okamoto Y

• KMID: 1737617
• DOI: http://doi.org/10.4142/jvs.2014.15.1.117

Abstract

Sixteen cases of malignant soft tissue sarcoma (STS; 10 canines and six felines) were treated with a novel triple therapy that combined photodynamic therapy, hyperthermia using indocyanine green with a broadband light source, and local chemotherapy after surgical tumor resection. This triple therapy was called photodynamic hyperthermal chemotherapy (PHCT). In all cases, the surgical margin was insufficient. In one feline case, PHCT was performed without surgical resection. PHCT was performed over an interval of 1 to 2 weeks and was repeated three to 21 times. No severe side effects, including severe skin burns, necrosis, or skin suture rupture, were observed in any of the animals. No disease recurrence was observed in seven out of 10 (70.0%) dogs and three out of six (50.0%) cats over the follow-up periods ranging from 238 to 1901 days. These results suggest that PHCT decreases the risk of STS recurrence. PHCT should therefore be considered an adjuvant therapy for treating companion animals with STS in veterinary medicine.

Keyword

cancer; chemotherapy; hyperthermia; PDT; soft tissue sarcoma

MeSH Terms

Animals
Antineoplastic Agents/*therapeutic use
Cat Diseases/drug therapy/surgery/*therapy
Cats
Combined Modality Therapy/veterinary
Dog Diseases/drug therapy/surgery/*therapy
Dogs
Hyperthermia, Induced/veterinary
Indocyanine Green/*therapeutic use
Photochemotherapy/veterinary
Photosensitizing Agents/*therapeutic use
Sarcoma/drug therapy/surgery/therapy/*veterinary
Antineoplastic Agents
Indocyanine Green
Photosensitizing Agents

Figure

• 

  Fig. 1 (A) Skin incision (arrow) in case C07. (B) PHCT was performed after surgery. The arrow indicates the broadband light source while the arrowheads indicate the thermometer and thermometer sensor.

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