Korean J Ophthalmol.  1993 Dec;7(2):65-69. 10.3341/kjo.1993.7.2.65.

Silicone oil keratopathy

• Choi WC
• Choi SK
• Lee JH

• KMID: 1735113
• DOI: http://doi.org/10.3341/kjo.1993.7.2.65

Abstract

Light microscopy and electron microscopic examination were carried out on the corneal buttons of two patients who required penetrating keratoplasty for treatment of corneal complication following the intraocular injection of silicone oil to repair recurrent retinal detachments in aphakic eyes. Light microscopic examination demonstrated increased cellularity and irregularity of collagen fibers of stromal layer, defect of endothelial cell layer and endothelial degeneration. Electron microscopy examination demonstrated marked decrease in endothelial cell population density, accompanied by flattening and thinning of the remaining cells and attenuation of cell borders. There were silicone droplets in the endothelial cell layer and collagenous layer posterior to endothelial layer. These findings are well correlated to clinical manifestation and are thought to be rather due to barrier effect of silicone oil than direct toxicity.

Keyword

silicone oil; keratopathy; histopathology

MeSH Terms

Adult
Corneal Diseases/*chemically induced/pathology/surgery
Descemet Membrane/ultrastructure
Endothelium, Corneal/drug effects/surgery/ultrastructure
Humans
Keratoplasty, Penetrating
Male
Recurrence
Retinal Detachment/surgery
Silicone Oils/*adverse effects
Silicone Oils