Yonsei Med J.  2004 Jun;45(3):527-532. 10.3349/ymj.2004.45.3.527.

Complete Resolution of Posttransplant Lymphoproliferative Disorder (Diffuse Large B-cell Lymphoma) with Reduction of Immunosuppressive Therapy

• Ryu HJ
• Hahn JS
• Kim YS
• Park K
• Yang WI
• Lee JD

• KMID: 1734137
• DOI: http://doi.org/10.3349/ymj.2004.45.3.527

Abstract

Posttransplant lymphoproliferative disorder (PTLD) is a serious complication of organ transplantation. PTLD is the disorder arising from the combined effects of Epstein-Barr virus associated lymphoid proliferation with the disruption of the normal immune control by the cytotoxic T cells. The treatment for PTLD is one of the most controversial topics in solid organ transplantation. It is well known that the initial management of PTLD is a reduction of immunosuppression. Early diagnosis and the early reduction in immunosuppression are essential even for monomorphic lymphoma. We report here on a case of the complete resolution of PTLD (diffuse large B cell lymphoma) which occurred after a drastic reduction of immunosuppression in a renal transplant recipient.

Keyword

PTLD; immunosuppression; reduction; resolution

MeSH Terms

Adult
Graft Rejection/*drug therapy
Human
Immunosuppressive Agents/*administration & dosage
*Kidney Transplantation
Korea
Lymphoma, Large-Cell, Diffuse/*drug therapy/radiography/radionuclid imaging
Male
Remission Induction
Tomography, Emission-Computed
Tomography, X-Ray Computed