J Korean Med Assoc.  2005 Feb;48(2):132-139. 10.5124/jkma.2005.48.2.132.

Gastroenterologic Disorders in the Elderly

• Kim JH
• Rhee PL

• KMID: 1723885
• DOI: http://doi.org/10.5124/jkma.2005.48.2.132

Abstract

No abstract available.

Keyword

Gastroenterologic disorders; Elderly; Pathophysiological changes; Clinical differences

MeSH Terms

Aged*
Humans

Reference

1. Holt PR. Gastrointestinal system: changes in morphology and cell proliferation. Aging (Milano). 1991. 3:392–394.

2. Russell RM. Changes in gastrointestinal function attributed to aging. Am J Clin Nutr. 1992. 55:6 Suppl. 1203S–1207S.

3. Hong WS. Clinically important gastroenterologic disorders in Korean elderly. Korean J Gastroenterol. 2003. 42:257–266.

4. Ren J, Shaker R, Kusano M, Podvrsan B, Metwally N, Sui Z, et al. Effect of aging on the secondary esophageal peristalsis: presbyesophagus revisited. Am J Physiol. 1995. 268:G772–G779.

5. Xie P, Ren J, Bardan E, Mittal RK, Sui Z, Shaker R. Frequency of gastroesophageal reflux events induced by pharyngeal water stimulation in young and elderly subjects. Am J Physiol. 1997. 272:G233–G237.

6. Grande L, Lacima G, Ros E, Pera M, Ascaso C, Pera C, et al. Deterioration of esophageal motility with age: a manometric study of 79 healthy subjects. Am J Gastroenterol. 1999. 94:1795–1801.

7. Amano K, Adachi K, Katsube T, Watanabe M, Kinoshita Y. Role of hiatus hernia and gastric mucosal atrophy in the development of reflux esophagitis in the elderly. J Gastroenterol Hepatol. 2001. 16:132–136.

8. Tack J, Vantrappen G. The aging oesophagus. Gut. 1997. 41:422–424.

9. Kennedy T, Jones R. The prevalence of gastro-oesophageal reflux symptoms in a UK population and the consultation behaviour of patients with these symptoms. Aliment Pharmacol Ther. 2000. 14:1589–1594.

10. Pilotto A. Aging and upper gastrointestinal disorders. Best Pract Res Clin Gastroenterol. 2004. 18:Suppl. 73–81.

11. Raiha I, Hietanen E, Sourander L. Symptoms of gastro-oesophageal reflux disease in elderly people. Age Ageing. 1991. 20:365–370.

12. Collen MJ, Abdulian JD, Chen YK. Gastroesophageal reflux disease in the elderly: more severe disease that requires aggressive therapy. Am J Gastroenterol. 1995. 90:1053–1057.

13. Maekawa T, Kinoshita Y, Okada A, Fukui H, Waki S, Matsushima Y, et al. Relationship between severity and symptoms of reflux oesophagitis in elderly patients in Japan. J Gastroenterol Hepatol. 1998. 13:927–930.

14. James OF, Parry-Billings KS. Comparison of omeprazole and histamine H2-receptor antagonists in the treatment of elderly and young patients with reflux oesophagitis. Age Ageing. 1994. 23:121–126.

15. Pilotto A, Leandro G, Franceschi M. Short-and long-term therapy for reflux oesophagitis in the elderly: a multi-centre, placebo-controlled study with pantoprazole. Aliment Pharmacol Ther. 2003. 17:1399–1406.

16. Pilotto A, Franceschi M, Leandro G, Novello R, Di Mario F, Valerio G. Long-term clinical outcome of elderly patients with reflux esophagitis: a six-month to three-year follow-up study. Am J Ther. 2002. 9:295–300.

17. Steinheber FU. Ageing and the stomach. Clin Gastroenterol. 1985. 14:657–688.

18. Moore JG, Tweedy C, Christian PE, Datz FL. Effect of age on gastric emptying of liquid-solid meals in man. Dig Dis Sci. 1983. 28:340–344.

19. Higham J, Kang JY, Majeed A. Recent trends in admissions and mortality due to peptic ulcer in England: increasing frequency of haemorrhage among older subjects. Gut. 2002. 50:460–464.

20. Pilotto A, Malfertheiner P. Review article: an approach to Helicobacter pylori infection in the elderly. Aliment Pharmacol Ther. 2002. 16:683–691.

21. Murakami M, Saita H, Takahashi Y, Kusaka S, Asagoe K, Matsumoto M, et al. Therapeutic effects of lansoprazole on peptic ulcers in elderly patients. J Clin Gastroenterol. 1995. 20:Suppl 2. S79–S82.

22. Pilotto A, Franceschi M, Leandro G, Bozzola L, Fortunato A, Meli S, et al. Efficacy of 7 day lansoprazole-based triple therapy for Helicobacter pylori infection in elderly patients. J Gastroenterol Hepatol. 1999. 14:468–475.

23. Ammon S, Treiber G, Kees F, Klotz U. Influence of age on the steady state disposition of drugs commonly used for the eradication of Helicobacter pylori. Aliment Pharmacol Ther. 2000. 14:759–766.

24. Pilotto A. Helicobacter pylori-associated peptic ulcer disease in older patients: current management strategies. Drugs Aging. 2001. 18:487–494.

25. Pilotto A, Franceschi M, Leandro G, Di Mario F. NSAID and aspirin use by the elderly in general practice: effect on gastrointestinal symptoms and therapies. Drugs Aging. 2003. 20:701–710.

26. Pilotto A, Franceschi M, Leandro G, Paris F, Niro V, D'Ambrosio LP, et al. The risk of upper gastrointestinal bleeding in elderly users of aspirin and other non-steroidal anti-inflammatory drugs: the role of gastroprotective drugs. Aging Clin Exp Res. 2003. 15:494–499.

27. Leandro G, Pilotto A, Franceschi M, Bertin T, Lichino E, Di Mario F. Prevention of acute NSAID-related gastroduodenal damage: a meta-analysis of controlled clinical trials. Dig Dis Sci. 2001. 46:1924–1936.

28. Brock J, Sauaia A, Ahnen D, Marine W, Schluter W, Scinto JD, et al. Process of care and outcomes for elderly patients hospitalized with peptic ulcer disease: results from a quality improvement project. JAMA. 2001. 286:1985–1993.

29. Jones AC, Coulson L, Muir K, Tolley K, Lophatananon A, Pringle M, et al. A nurse-delivered advice intervention can reduce chronic non-steroidal anti-inflammatory drug use in general practice: a randomized controlled trial. Rheumatology (Oxford). 2002. 41:14–21.

30. Mamdani M, Rochon PA, Juurlink DN, Kopp A, Anderson GM, Austin PC, et al. Observational study of upper gastrointestinal haemorrhage in elderly patients given selective cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs. BMJ. 2002. 325:624.

31. White WB, Whelton A. Cardiovascular events and COX-2 inhibitors. JAMA. 2001. 286:2811–2812.

32. Yodfat Y. Is there a future for COX-2 inhibitors? Harefuah. 2004. 143:820–824.

33. Arai T, Esaki Y, Inoshita N, Sawabe M, Kasahara I, Honma N, et al. Pathologic characteristics of gastric cancer in the elderly: a retrospective study of 994 surgical patients. Gastric Cancer. 2004. 7:154–159.

34. Song BC, Choi JW, Choi WB, Youn KH, Joo YH, Joo KR, et al. Clinicopathological features of gastric carcinoma in the Korean elderly. J Korean Geriatr Soc. 1997. 1:35–42.

35. Kitagawa M, Utsuyama M, Kurata M, Yamamoto K, Yuasa Y, Arai T, et al. Cancer and aging: symposium of the 27th annual meeting of the Japanese society for biomedical gerontology, Tokyo. Cancer Immunol Immunother. 2004.

36. Inoshita N, Yanagisawa A, Arai T, Kitagawa T, Hirokawa K, Kato Y. Pathological characteristics of gastric carcinomas in the very old. Jpn J Cancer Res. 1998. 89:1087–1092.

37. Katai H, Sasako M, Sano T, Fukagawa T. Gastric cancer surgery in the elderly without operative mortality. Surg Oncol. 2004. 13:235–238.

38. Madsen JL, Graff J. Effects of ageing on gastrointestinal motor function. Age Ageing. 2004. 33:154–159.

39. Rumiantsev VG, Bondarenko EIu. Chronic constipations in elderly people. Eksp Klin Gastroenterol. 2004. 109:48–54.

40. Wald A. Constipation and fecal incontinence in the elderly. Semin Gastrointest Dis. 1994. 5:179–188.

41. Camilleri M, Lee JS, Viramontes B, Bharucha AE, Tangalos EG. Insights into the pathophysiology and mechanisms of constipation, irritable bowel syndrome, and diverticulosis in older people. J Am Geriatr Soc. 2000. 48:1142–1150.

42. Youn SJ, Kim NY, Kim YT, Jung HC, Lee HS, Yoon YB, et al. Colorectal polyp in Korea. Korean J Gastroenterol. 1991. 23:450–458.

43. Lee DH, Cho MK, Yu CS, Kim HC, Jung HY, Yang SK, et al. Clinicopathologic study of colorectal polyps. Korean J Gastroenterol. 2000. 36:302–316.

44. Provenzale D, Garrett JW, Condon SE, Sandler RS. Risk for colon adenomas in patients with rectosigmoid hyperplastic polyps. Ann Intern Med. 1990. 113:760–763.

45. Au HJ, Mulder KE, Fields AL. Systematic review of management of colorectal cancer in elderly patients. Clin Colorectal Cancer. 2003. 3:165–171.

46. Berner Y, Vigder C, Stern M, Feldman J. Inflammatory Bowel diseases in the elderly. Harefuah. 2003. 142:188–192.

47. Piront P, Louis E, Latour P, Plomteux O, Belaiche J. Epidemiology of inflammatory bowel diseases in the elderly in the province of Liege. Gastroenterol Clin Biol. 2002. 26:157–161.

48. Wynne HA, Cope LH, Mutch E, Rawlins MD, Woodhouse KW, James OF. The effect of age upon liver volume and apparent liver blood flow in healthy man. Hepatology. 1989. 9:297.

49. Woodhouse KW, James OF. Hepatic drug metabolism and ageing. Br Med Bull. 1990. 46:22–35.

50. Kim MH, Lim BC, Myung SJ, Lee SK, Ohrr HC, Roe IH, et al. Epidemiological study on Korean gallstone disease: a nationwide cooperative study. Dig Dis Sci. 1999. 44:1674–1683.

51. Lee SK, Seo DW, Myung SJ, Park ET, Lim BC, Yoo KS, et al. Percutaneous transhepatic cholangioscopic treatment for hepatolithiasis: an evaluation of long-term results and risk factors for recurrence. Gastrointest Endosc. 2001. 53:318–323.

52. Kim CD. Current status of acute pancreatitis in Korea. Korean J Gastroenterol. 2003. 42:1–11.

53. Kim JP, Kim SJ, Lee JH, Kim SW, Choi MG, Yu HJ. Surgery in the aged in Korea. Arch Surg. 1998. 133:18–23.

54. Bender JS. Approach to the acute abdomen. Med Clin North Am. 1989. 73:1413–1422.

55. Hendrickson M, Naparst TR. Abdominal surgical emergencies in the elderly. Emerg Med Clin North Am. 2003. 21:937–969.