Clin Orthop Surg.  2010 Dec;2(4):260-263. 10.4055/cios.2010.2.4.260.

Intradural Extramedullary Tuberculoma Mimicking En Plaque Meningioma

Affiliations
  • 1Department of Orthopedic Surgery, Wonkwang University Hospital, Iksan, Korea.
  • 2Department of Orthopedic Surgery, Wonkwang University Sanbon Hospital, Gunpo, Korea. niceo@daum.net

Abstract

A 24-year-old man with tuberculosis meningitis developed acute paraplegia and sensory disturbances 5 weeks after receiving conventional antituberculous therapy. Magnetic resonance imaging revealed an intradural extramedullary long segmental mass mimicking en plaque meningioma at the T2-T6 vertebrae levels. Prompt surgical decompression was performed. A histology examination of the mass revealed a tuberculoma. After surgery, the patient showed improved motor power and a normal bladder function. Intradural extramedullary tuberculoma of the spinal cord is rare complication of tuberculosis meningitis, which can occur as a response to conventional antituberculous therapy.

Keyword

Tuberculoma; Spinal cord; En plaque meningioma

MeSH Terms

Diagnosis, Differential
Humans
Male
Meningeal Neoplasms/*diagnosis
Meningioma/*diagnosis
Spinal Cord Diseases/*diagnosis/surgery
Thoracic Vertebrae
Tuberculoma/*diagnosis/surgery
Tuberculosis, Meningeal/*diagnosis/surgery
Young Adult

Figure

  • Fig. 1 T2-weighted sagittal (A) and enhanced T1-weighted sagittal (B) section of magnetic resonance imaging scan of a thoracic spine,showing an intradural extramedullary mass extending from T2 through T6 and compressing the spinal cord.

  • Fig. 2 Photomicrograph shows chronic granulomatous inflammation with neutrophil infiltrate under low and high magnification (A, H&E × 200; B, H&E × 400).

  • Fig. 3 Postoperative 3 month follow-up magnetic resonance imaging scan of the thoracic and lumbar regions. Laminectomy state of thoracic spine (A). Typical finding of tuberculosis spondylitis L5-S1 with multiple abscess (B).


Reference

1. Mirzai H. Tuberculoma of the cervical spinal canal mimicking en plaque meningioma. J Spinal Disord Tech. 2005. 18(2):197–199.
Article
2. Kumar R, Prakash M, Jha S. Paradoxical response to chemotherapy in neurotuberculosis. Pediatr Neurosurg. 2006. 42(4):214–222.
Article
3. Luo L, Pino J. An intradural extramedullary tuberculoma of the spinal cord in a non-HIV-infected patient: case report and review of the literature. Lung. 2006. 184(3):187–193.
Article
4. Skendros P, Kamaria F, Kontopoulos V, Tsitouridis I, Sidiropoulos L. Intradural, eextramedullary tuberculoma of the spinal cord as a complication of tuberculous meningitis. Infection. 2003. 31(2):115–117.
Article
5. Roca B. Intradural extramedullary tuberculoma of the spinal cord: a review of reported cases. J Infect. 2005. 50(5):425–431.
Article
6. Kumar R, Kasliwal MK, Srivastava R, Sharma BS. Tuberculoma presenting as an intradural extramedullary lesion. Pediatr Neurosurg. 2007. 43(6):541–543.
Article
7. Takahashi H, Ito S, Kojima S, Tanno T, Hattori T. Intradural extramedullary tuberculoma of the thoracic spine: paradoxical response to antituberculous therapy. Intern Med. 2008. 47(8):797–798.
Article
8. Compton JS, Dorsch NW. Intradural extramedullary tuberculoma of the cervical spine: case report. J Neurosurg. 1984. 60(1):200–203.
9. Muthukumar N, Sureshkumar V. Concurrent syringomyelia and intradural extramedullary tuberculoma as late complications of tuberculous meningitis. J Clin Neurosci. 2007. 14(12):1225–1230.
Article
10. Narita M, Ashkin D, Hollender ES, Pitchenik AE. Paradoxical worsening of tuberculosis following antiretroviral therapy in patients with AIDS. Am J Respir Crit Care Med. 1998. 158(1):157–161.
Article
Full Text Links
  • CIOS
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr