Korean J Intern Med.  2005 Jun;20(2):177-179. 10.3904/kjim.2005.20.2.177.

A Case of Erythema Nodosum and Serositis Associated with Myelodysplastic Syndrome

• Choi JH
• Ahn MJ
• Park YW
• Oh HS
• Lee YY
• Kim IS

• KMID: 1718043
• DOI: http://doi.org/10.3904/kjim.2005.20.2.177

Abstract

Myelodysplastic syndrome (MDS) is a heterogenous group of stem cell disorders usually characterized by progressive refractory cytopenias, which could progress to acute myeloid leukemia. MDS may be associated with a wide spectrum of skin lesions, including neoplastic cell infiltration, Sweet's syndrome, pyoderma gangrenosum, erythema elevatum diutinum, vasculitis, and panniculitis. However, erythema nodosum is rarely associated with MDS. Unusual rheumatologic manifestations in patients with MDS also have been reported, which range from asymptomatic serological abnormalities to classic connective tissue disorders such as Sjogren's syndrome, relapsing polychondritis, systemic lupus erythematosus, rheumatoid arthritis and mixed connective tissue disease. However, concurrent erythema nodosum and serositis has rarely been reported. We describe a case of MDS with erythema nodosum and immune-mediated pericardial effusion in a 34-year-old woman.

Keyword

Myelodysplastic syndrome; Erythema nodosum; Pericardial effusion

MeSH Terms

Adult
Biopsy
Diagnosis, Differential
Erythema Nodosum/*complications/diagnosis/drug therapy
Female
Follow-Up Studies
Glucocorticoids/therapeutic use
Humans
Myelodysplastic Syndromes/*complications/diagnosis/drug therapy
Prednisone/therapeutic use
Serositis/*complications/diagnosis/drug therapy
Tomography, X-Ray Computed