Korean J Intern Med.
2009 Sep;24(3):270-273. 10.3904/kjim.2009.24.3.270.
A Case of Idiopathic Adulthood Ductopenia
- Affiliations
-
- 1Department of Internal Medicine, Chungbuk National University College of Medicine and Medical Research Institute, Cheongju, Korea. smpark@chungbuk.ac.kr
- 2Department of Pathology, Chungbuk National University College of Medicine and Medical Research Institute, Cheongju, Korea.
- 3Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- KMID: 1717952
- DOI: http://doi.org/10.3904/kjim.2009.24.3.270
Abstract
- Idiopathic adulthood ductopenia (IAD) is a chronic cholestatic liver disease of unknown etiology characterized by adult onset, an absence of autoantibodies, inflammatory bowel disease, and a loss of interlobular bile ducts. In the present report, a case fulfilling the IAD criteria is described. A 19-year-old man was admitted to the hospital for persistent elevation of transaminases and alkaline phosphatase without clinical symptoms. Viral hepatitis markers and autoantibodies were absent. The patient had a normal extrahepatic biliary tree and had no evidence of inflammatory bowel disease. A liver biopsy specimen showed absence of interlobular bile ducts from 58% of the portal tracts. He was diagnosed with IAD and was treated with ursodeoxycholic acid.
