Lab Anim Res.  2013 Dec;29(4):226-228. 10.5625/lar.2013.29.4.226.

Single coronary artery originating from the right aortic sinus without a left anterior descending and circumflex artery in conventional swine

• Lim KS
• Jeong MH
• Park JE
• Bae IH
• Park DS
• Kim JM
• Kim JH
• Sim DS
• Park KH
• Hong YJ
• Ahn Y

• KMID: 1716218
• DOI: http://doi.org/10.5625/lar.2013.29.4.226

Abstract

Single coronary artery is a rare coronary artery anomaly. Very few previous reports of this anatomical malformation in swine have been found. A 22 kg Yorkshire X Landrace F1 crossbred castrated male swine was presented for enrollment in a coronary stent implantion study. Coronary angiography revealed a single coronary artery arising from the right aortic sinus. The right coronary artery and anomalous left coronary artery were implanted with novel coronary stents without any side effects.

Keyword

Coronary stents; coronary artery; coronary artery malformations

MeSH Terms

Arteries*
Coronary Angiography
Coronary Vessels*
Humans
Male
Sinus of Valsalva*
Stents
Swine*

Figure

• 

  Figure 1 (1) The normal left coronary artery divides into the left anterior descending artery (LAD, white arrow) and left circumflex artery (LCX, black arrow). (2) The normal right coronary artery (RCA) arises from the right aortic sinus (opened arrow).

• 

  Figure 2 (1) On angiography, the left coronary artery did not exist. (2) Right coronary angiography revealed an anomalous left coronary artery (black arrow) originating as a separate branch from the right coronary artery (RCA, opened arrow).

• 

  Figure 3 (1) Coronary stent was implanted in RCA. (2) The other stent was implanted in the anomalous left coronary artery. The stents were deployed by inflating the balloon and the resulting stent-to-artery ratio was 1.3:1.

• 

  Figure 4 (1) Opened arrow indicates the implanted coronary stent. (2) Coronary angiograms were obtained immediately after stent implantation. Angiogram showed that side effects such as acute stent thrombosis did not occur in the stent site.

Reference

1. Angelini P. Normal and anomalous coronary arteries: definitions and classification. Am Heart J. 1989; 117(2):418–434. PMID: 2644796.

2. Angelini P, Velasco JA, Flamm S. Coronary anomalies: incidence, pathophysiology, and clinical relevance. Circulation. 2002; 105(20):2449–2454. PMID: 12021235.

3. Crick SJ, Sheppard MN, Ho SY, Gebstein L, Anderson RH. Anatomy of the pig heart: comparisons with normal human cardiac structure. J Anat. 1998; 193(Pt 1):105–119. PMID: 9758141.

4. Erdogan O, Buyuklu M, Aktoz M. Anomalous origin of the right coronary artery from the left anterior descending artery in a patient with single left coronary artery: a rare coronary artery anomaly and review of the literature. Int J Cardiol. 2008; 127(2):280–283. PMID: 17658630.

5. Kaku B, Shimizu M, Yoshio H, Ino H, Mizuno S, Kanaya H, Ishise S, Mabuchi H. Clinical features of prognosis of Japanese patients with anomalous origin of the coronary artery. Jpn Circ J. 1996; 60(10):731–741. PMID: 8933235.

6. Kim D, Jeong MH, Lee KH, Lee MG, Park KH, Sim DS, Yoon NS, Yoon HJ, Kim KH, Hong YJ, Kim JH, Ahn Y, Cho JG, Park JC, Kang JC. Successful primary percutaneous coronary intervention in a patient with acute myocardial infarction and single coronary artery ostium. Korean Circ J. 2012; 42(4):284–287. PMID: 22563344.

7. Matthews KA, Gogas BD, Sumida A, Nagai H, King Iii SB, Chronos N, Hou D. Anomalous right coronary artery originating from the left sinus of Valsalva in a Yucatan minipig. Comp Med. 2012; 62(2):127–130. PMID: 22546919.

8. Nguyen Din Cat A, Sainte-Marie Y, Jaisser F. Animal models in cardiovascular diseases: new insights from conditional models. Handb Exp Pharmacol. 2007; 178:377–405. PMID: 17203664.

9. Nowlan P. Laboratory animal medicine. Vet Rec. 2003; 153(24):758. PMID: 14703185.

10. Yamanaka O, Hobbs RE. Coronary artery anomalies in 126,595 patients undergoing coronary arteriography. Cathet Cardiovasc Diagn. 1990; 21(1):28–40. PMID: 2208265.

11. Yuksel S, Meric M, Soylu K, Gulel O, Zengin H, Demircan S, Yilmaz O, Sahin M. The primary anomalies of coronary artery origin and course: A coronary angiographic analysis of 16,573 patients. Exp Clin Cardiol. 2013; 18(2):121–123. PMID: 23940436.

12. Zaragoza C, Gomez-Guerrero C, Martin-Ventura JL, Blanco-Colio L, Lavin B, Mallavia B, Tarin C, Mas S, Ortiz A, Egido J. Animal models of cardiovascular diseases. J Biomed Biotechnol. 2011; 2011:497841. PMID: 21403831.