Korean J Parasitol.  2011 Sep;49(3):273-275. 10.3347/kjp.2011.49.3.273.

Hypersensitive Reaction to Praziquantel in a Clonorchiasis Patient

• Lee JM
• Lim HS
• Hong ST

• KMID: 1715650
• DOI: http://doi.org/10.3347/kjp.2011.49.3.273

Abstract

Praziquantel is the drug of choice for clonorchiasis. Since clonorchiasis is endemic in most river basins, praziquantel has been widely used for 30 years in Korea. A 54-year-old Korean woman suffered from hypersensitive reactions, such as nausea, dyspnea, rash, and urticaria after taking the first dose of praziquantel to treat clonorchiasis. She ingested one dose again and the same symptoms appeared, and she was treated at a clinic with anti-histamines. She tried one more dose with anti-histamines but found the same symptoms. Later, she was found to pass eggs of Clonorchis sinensis and medicated with flubendazole. The hypersensitive reaction to praziquantel is rare but occurs. This is the 5th case report in the world.

Keyword

Clonorchis sinensis; clonorchiasis; praziquantel; hypersensitive reaction

MeSH Terms

Animals
Anthelmintics/*administration & dosage/*adverse effects
Clonorchiasis/*complications/*drug therapy
Clonorchis sinensis/isolation & purification
Drug Hypersensitivity/*diagnosis/drug therapy/pathology
Feces/parasitology
Female
Histamine Antagonists/administration & dosage
Humans
Mebendazole/administration & dosage/analogs & derivatives
Middle Aged
Praziquantel/*administration & dosage/*adverse effects
Republic of Korea