J Korean Med Sci.  2007 Feb;22(1):146-148. 10.3346/jkms.2007.22.1.146.

A De Novo Centric Fission of Chromosome 11 in a Patient with Recurrent Miscarriages

• Shim SH
• Lee CH
• Lee JY
• Shin ES
• Kyhm JH
• Park MI
• Chung SR
• Cho YH

• KMID: 1713255
• DOI: http://doi.org/10.3346/jkms.2007.22.1.146

Abstract

We report on a de novo centric fission of chromosome 11 in a healthy female referred for chromosome analysis due to recurrent miscarriages. Both fission products were mitotically stable. This centric fission of chromosome 11 appears to have no clinical significance for this patient other than recurrent miscarriages.

Keyword

Chromosomal Fission; Centric Fission; In Situ Hybridization, Fluorescence; Primed In Situ Labeling

MeSH Terms

Humans
Female
*Chromosomes, Human, Pair 11
*Chromosome Aberrations
Adult
Abortion, Habitual/*genetics

Figure

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  Fig. 1 Routine GTG-banding patterns of centric fission of chromosome 11. The karyotype according to ISCN (1995) is 47,XX,-11, +fis(11)(p10),+fis(11)(q10).

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  Fig. 2 A whole chromosome painting probe was applied to a metaphase spread of centric fission of chromosome 11. A white and a red arrow indicate a short arm and a long arm of chromosome 11, respectively.

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  Fig. 3 The PRINS (primed in situ labeling) reaction with a oligonucleotide primer specific for the centromere of chromosome 11 reveals three distinct fluorescent spots on the centromeres of chromosome 11. The fluorescent signal on the short arm fragment of fis (11) was stronger than that of long arm.

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