Korean J Radiol.  2013 Jun;14(3):423-429. 10.3348/kjr.2013.14.3.423.

Parallel Shunt for the Treatment of Transjugular Intrahepatic Portosystemic Shunt Dysfunction

Affiliations
  • 1Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, China. simonlixiao@gmail.com
  • 2Department of Interventional Radiology, West China Hospital, Sichuan University, Chengdu 610041, China.
  • 3Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China.

Abstract


OBJECTIVE
To investigate the safety, efficacy and long-term patency of parallel shunts (PS) in the management of the transjugular intrahepatic portosystemic shunt (TIPS) dysfunction.
MATERIALS AND METHODS
Between March 2007 and October 2010, 18 patients (13 men and 5 women) who underwent TIPS revision with the creation of PS were evaluated retrospectively. In the first 10 patients, a 10-mm-diameter Wallgraft endoprosthesis was deployed; in the latter 8 patients, an 8-mm-diameter Fluency endoprosthesis was deployed.
RESULTS
The creation of PS was technically successful in all patients. The mean +/- standard deviation portosystemic pressure gradient before and after the procedure was 25.5 +/- 7.3 mm Hg (range, 16-37 mm Hg) and 10.9 +/- 2.3 mm Hg (range, 7-16 mm Hg), respectively. The duration of follow-up was 16.7 +/- 10.8 months (range, 6-42 months). The primary shunt patency rates at 12 months after the creation of PS was 70% with Wallgraft endoprostheses and 87.5% with Fluency endoprostheses.
CONCLUSION
TIPS revision with the creation of PS is a safe, effective and durable method for treating shunt dysfunction.

Keyword

Transjugular intrahepatic portosystemic shunt; Parallel shunt; Revision; Stent-graft

MeSH Terms

Adult
Aged
Blood Pressure Determination
Female
Humans
Male
Middle Aged
Polytetrafluoroethylene
Portasystemic Shunt, Transjugular Intrahepatic/adverse effects/*methods
Prosthesis Design
Reoperation/methods
Retrospective Studies
Stents
Polytetrafluoroethylene

Figure

  • Fig. 1 69-year-old man following TIPS creation with Wallgraft endoprosthesis presented with recurrent variceal bleeding. A. Direct portogram showed occluded initial stent and numerous collaterals veins. B. After PS creation with second Wallgraft endoprosthesis, portogram showed good flow through shunt, without opacification of collateral veins. C. PS dysfunction developed 13 months later, and third PS was created with Wallgraft endoprosthesis. D. Final portogram showed widely patent shunt. TIPS = transjugular intrahepatic portosystemic shunt, PS = parallel shunt

  • Fig. 2 40-year-old man with alcoholic liver cirrhosis and recurrent variceal bleeding. A. Initial portogram showed occluded intrahepatic portosystemic shunt. B. Final portogram after revision with PS creation showed good flow through shunt. This PS was created with Fluency endoprosthesis. PS = parallel shunt


Reference

1. Boyer TD, Haskal ZJ. American Association for the Study of Liver Diseases. The Role of Transjugular Intrahepatic Portosystemic Shunt (TIPS) in the Management of Portal Hypertension: update 2009. Hepatology. 2010. 51:306.
2. Richter GM, Palmaz JC, Nöldge G, Rössle M, Siegerstetter V, Franke M, et al. [The transjugular intrahepatic portosystemic stent-shunt. A new nonsurgical percutaneous method]. Radiologe. 1989. 29:406–441.
3. Haskal ZJ, Pentecost MJ, Soulen MC, Shlansky-Goldberg RD, Baum RA, Cope C. Transjugular intrahepatic portosystemic shunt stenosis and revision: early and midterm results. AJR Am J Roentgenol. 1994. 163:439–444.
4. Saxon RS, Ross PL, Mendel-Hartvig J, Barton RE, Benner K, Flora K, et al. Transjugular intrahepatic portosystemic shunt patency and the importance of stenosis location in the development of recurrent symptoms. Radiology. 1998. 207:683–693.
5. Nishimine K, Saxon RR, Kichikawa K, Mendel-Hartvig J, Timmermans HA, Shim HJ, et al. Improved transjugular intrahepatic portosystemic shunt patency with PTFE-covered stent-grafts: experimental results in swine. Radiology. 1995. 196:341–347.
6. Tanihata H, Saxon RR, Kubota Y, Pavcnik D, Uchida BT, Rosch J, et al. Transjugular intrahepatic portosystemic shunt with silicone-covered Wallstents: results in a swine model. Radiology. 1997. 205:181–184.
7. Cura M, Cura A, Suri R, El-Merhi F, Lopera J, Kroma G. Causes of TIPS dysfunction. AJR Am J Roentgenol. 2008. 191:1751–1757.
8. Rossi P, Salvatori FM, Fanelli F, Bezzi M, Rossi M, Marcelli G, et al. Polytetrafluoroethylene-covered nitinol stent-graft for transjugular intrahepatic portosystemic shunt creation: 3-year experience. Radiology. 2004. 231:820–830.
9. Bureau C, Garcia-Pagan JC, Otal P, Pomier-Layrargues G, Chabbert V, Cortez C, et al. Improved clinical outcome using polytetrafluoroethylene-coated stents for TIPS: results of a randomized study. Gastroenterology. 2004. 126:469–475.
10. Cejna M, Peck-Radosavljevic M, Thurnher SA, Hittmair K, Schoder M, Lammer J. Creation of transjugular intrahepatic portosystemic shunts with stent-grafts: initial experiences with a polytetrafluoroethylene-covered nitinol endoprosthesis. Radiology. 2001. 221:437–446.
11. Rössle M, Haag K, Ochs A, Sellinger M, Nöldge G, Perarnau JM, et al. The transjugular intrahepatic portosystemic stent-shunt procedure for variceal bleeding. N Engl J Med. 1994. 330:165–171.
12. Ochs A, Rössle M, Haag K, Hauenstein KH, Deibert P, Siegerstetter V, et al. The transjugular intrahepatic portosystemic stent-shunt procedure for refractory ascites. N Engl J Med. 1995. 332:1192–1197.
13. Rössle M, Gerbes AL. TIPS for the treatment of refractory ascites, hepatorenal syndrome and hepatic hydrothorax: a critical update. Gut. 2010. 59:988–1000.
14. García-Pagán JC, Caca K, Bureau C, Laleman W, Appenrodt B, Luca A, et al. Early use of TIPS in patients with cirrhosis and variceal bleeding. N Engl J Med. 2010. 362:2370–2379.
15. Feldstein VA, Patel MD, LaBerge JM. Transjugular intrahepatic portosystemic shunts: accuracy of Doppler US in determination of patency and detection of stenoses. Radiology. 1996. 201:141–147.
16. Tzeng WS, Wu RH, Lin CY, Chen JJ, Sheu MJ, Koay LB, et al. Prediction of mortality after emergent transjugular intrahepatic portosystemic shunt placement: use of APACHE II, Child-Pugh and MELD scores in Asian patients with refractory variceal hemorrhage. Korean J Radiol. 2009. 10:481–489.
17. Siegerstetter V, Huber M, Ochs A, Blum HE, Rössle M. Platelet aggregation and platelet-derived growth factor inhibition for prevention of insufficiency of the transjugular intrahepatic portosystemic shunt: a randomized study comparing trapidil plus ticlopidine with heparin treatment. Hepatology. 1999. 29:33–38.
18. Clark TW, Agarwal R, Haskal ZJ, Stavropoulos SW. The effect of initial shunt outflow position on patency of transjugular intrahepatic portosystemic shunts. J Vasc Interv Radiol. 2004. 15(2 Pt 1):147–152.
19. Dabos KJ, Stanley AJ, Redhead DN, Jalan R, Hayes PC. Efficacy of balloon angioplasty, restenting, and parallel shunt insertion for shunt insufficiency after transjugular intrahepatic portosystemic stent-shunt (TIPSS). Minim Invasive Ther Allied Technol. 1998. 7:287–293.
20. Helmy A, Redhead DN, Stanley AJ, Hayes PC. The natural history of parallel transjugular intrahepatic portosystemic stent shunts using uncovered stent: the role of host-related factors. Liver Int. 2006. 26:572–578.
21. Echenagusia M, Rodriguez-Rosales G, Simo G, Camuñez F, Bañares R, Echenagusia A. Expanded PTFE-covered stent-grafts in the treatment of transjugular intrahepatic portosystemic shunt (TIPS) stenoses and occlusions. Abdom Imaging. 2005. 30:750–754.
22. Chan CY, Liang PC. Recanalization of an occluded intrahepatic portosystemic covered stent via the percutaneous transhepatic approach. Korean J Radiol. 2010. 11:469–471.
23. Haskal ZJ, Duszak R Jr, Furth EE. Transjugular intrahepatic transcaval portosystemic shunt: the gun-sight approach. J Vasc Interv Radiol. 1996. 7:139–142.
24. Haskal ZJ. Improved patency of transjugular intrahepatic portosystemic shunts in humans: creation and revision with PTFE stent-grafts. Radiology. 1999. 213:759–766.
25. Cejna M, Peck-Radosavljevic M, Thurnher S, Schoder M, Rand T, Angermayr B, et al. ePTFE-covered stent-grafts for revision of obstructed transjugular intrahepatic portosystemic shunt. Cardiovasc Intervent Radiol. 2002. 25:365–372.
26. Park JS, Oh JH, Kim DY, Park YK, Park SJ, Kim SJ. Effects of intraluminal irradiation with Holmium-166 for TIPS stenosis: experimental study in a swine model. Korean J Radiol. 2007. 8:127–135.
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