J Korean Neurosurg Soc.  1993 Dec;22(12):1295-1303.

A Comparative Study of BudR, AgNOR's, and PCNA in Benign and Malignant Astrocytoma

• Lee WC
• Shin MS
• Jung N
• Huh SK
• Lee HK

Abstract

In 14 cases of astocytoma, we performed a comparative study of BudR, AgNOR's, and PCNA with histopathology. Fourteen astrocytomas were classified histopathologically into low grade, anaplastic, and G.M.(glioblastoma multiforme) groups. These comprised 3 G.M., 5 anaplastic astrocytomas, and 6 low grade astrocytomas. The mean BudR-LI(Labeling Index) was statistically different(P<0.005) between G.M.(10.4), anaplastic astrocytoma(3.6), and low grade astrocytoma(1.3). On the basis of correlation between BudR-LI and histopathology which was reported in 1989 at PMC, we examined the relationship between BudR-LI and AgNOR's count, and between BudR-LI and PCNA-LI, Both AgNOR's count and PCNA-LI did not correlate with BudR-LI, and also not with histopathology. This study indicates that, at present, for prognosis and differentiation between malignant and benign astrocytoma, histopathology and BudR-LI are important.

Keyword

Astroctoma; Bromodeoxyuridine(BudR); Argyrophilic nucleolar organizer regions(AgNOR's); Proliferating cell nuclear antigen(PCNA); Histopathology; Cell kinetics

MeSH Terms

Astrocytoma*
Bromodeoxyuridine*
Prognosis
Proliferating Cell Nuclear Antigen*
Bromodeoxyuridine
Proliferating Cell Nuclear Antigen