Korean J Dermatol.  1984 Oct;22(5):467-470.

An Immunofluorescent Study of Majocchi' s Disease

• Lee CW
• Eun HC
• Kim JH

Abstract

Majocchi's disease is one of chronic vascular disorders of the skin, histologically showing capillaritis with lymphoid cell infiltration. Although the hypothesis of delayed type hypersensitivity reaction against foreign antigen is proposed as the mechanism producing this condition, there are much yet to be defined. We tried to examine the lesional skin of five patients with Majocchi's disease by the direct immunofluorescence with anti-human immunoglobulins, C 3, and fibrin. As a result we found the deposition of immunoglobulins (M, and G) in papillary blood vessels in four patients, and C 3 and fibrin were found in all five patients. C3 was also found at the dermoepidermal junction in three patients. These findings suggest the posssibility that antibody mediated immunologic processes may alsobe involved in the pathogenesis of this disorder. With this observation Majocchis disease could be considered as a chronic immune vasculitis.

MeSH Terms

Blood Vessels
Fibrin
Fluorescent Antibody Technique, Direct
Humans
Hypersensitivity
Immunoglobulins
Lymphocytes
Skin
Vasculitis
Fibrin
Immunoglobulins