Korean J Dermatol.  1980 Oct;18(5):439-446.

Two Cases of Acute Febrile Neutrophilic Dermatosis (Sweet's Syndrome)

• Cho NJ
• Choi DY
• Son SJ
• Shin S

Abstract

Acute febrile neutrophilic dermatosis, which was introduced to the dermatologic literature by Sweet in 1964, is characterized by persistent high fever and preceding upper respiratory infection like symptoms, polymorphonuclear leukocytosis in the peripheral blood, raised painful plaques on the limbs, face and neck, histologically a dense dermal infiltration with polymorphonuclear leukocyte, dramatic response to corticosteroids, and the absence of scarring. Case 1 was a 35 year-old female who had suffered from malaise, sore throat, and fever 3 to 7 days before the each episode of the cutaneous manifestation. Painful, red, raised, well-demarcated plaques appeared on the face with tendency of recurrences, and was accompanied by a few, small, shallow ulcerations on the lower Iip and tongue, and conjunctivitis. Polymorphonuclear leukocytosis (10400 with 65%, 11600 with 75%) and elevated ESR(23mm/hr, 19mm/hr) were found on two occasions. Histologically a dense inflammatory cell infiltration composed predominantly of polymorphonuclear neutrophils, small round cells, and a few eosinophils were seen in the dermis and subcutis, especially around the dermal capillaries. Alao there were many nuclear debris and marked endothelial cell proliferations. (countinued...)

MeSH Terms

Adrenal Cortex Hormones
Adult
Capillaries
Cicatrix
Conjunctivitis
Dermis
Endothelial Cells
Eosinophils
Extremities
Female
Fever
Humans
Leukocytosis
Neck
Neutrophils
Pharyngitis
Recurrence
Sweet Syndrome*
Tongue
Ulcer
Adrenal Cortex Hormones