The Clinical Effect of Oxolinic Acid on Genitourinary Tract Infection

Song, Sang Il; Lee, Jhy Bok

Abstract

Oxolinic acid is a weak-organic acid which developed recently from Nalidixic acid. Author reports a clinical observation about the effect of oxolinic acid on patients of genito-urinary tract infection, who visited to our O.P.D. from May 1976 to Nov. 1976. Daily dose is 1.5gm per oral for 5-28 days. 1. Among 12 cases of nongonococcal urethritis, excellent and good effects are obtained in 10 cases. 2. Among 9 cases of Gonococcal urethritis, excellent effects are resulted in 7 cases. 3. Among 6 cases of acute cystitis, excellent in 4 cases and good result in 2 cases are noted. 4. Among 5 cases of chronic prostatitis, only 1 case excellent and good effects are noted in 2 cases. 5. Among 3 cases of epididymitis, good effects are seen in 2 cases. 6. On 2 cases of chronic cystitis, 1 case is excellent and no effect in 1 case is noted. 7. On 1 case of pyelonephritis, no effect is obtained. 8. Oxolinic acid has the antibacterial activity in 11 cases of 17 cases staphylococcus & streptococcus infections, 7 cases of 9 cases gonococcus infections, and 1 case of 2 cases proteus infections. No significant toxicity is seen through the course of therapy.