Korean Circ J.  1980 Dec;10(1):51-55. 10.4070/kcj.1980.10.1.51.

A Clinical Study on Pentoxifylline (Trental(R)) in the Treatment of Cerebrovascular Disease

• Lee MM
• Hong KP
• Oh BH
• Choi YS
• Seo J
• Lee YW

• KMID: 1668326
• DOI: http://doi.org/10.4070/kcj.1980.10.1.51

Abstract

Pentoxifylline (Trental(R)) is a drug which blocks pathophysiologic process of cerebrovascular disease by inhibiting platelet aggregation, improving cerebral microcirculation preventing development of cerebral edema. In an attempt to evaluate the effect of pentoxifylline for the treatment of 25 patients (male 17 cases, female 8 cases) with cerebrovasculaar disease, we administered pentoxifylline 600mg daily in devided dosage for 1 to 7 months. Most of them were patients with cerebral thrombosis (52%), cerebral embolism (24%), cerebral hemorrhage (12%) and transient ischemic attack (12%). Clinical effects were evaluated at least 1 month later by the criteria using scoring method of serverity of symptoms. In summary, definite effect was found in 15 cases (60%), mild effect in 6 cases (24%) and no efect or aggravation in 4 cases (16%), especially in patients with cerebral hemorrhage. During treatment there was no significant side effect except mild elevation of serum creatinine in one case who was associated with chronic renal failure.

MeSH Terms

Brain Edema
Cerebral Hemorrhage
Creatinine
Female
Humans
Intracranial Embolism
Intracranial Thrombosis
Ischemic Attack, Transient
Kidney Failure, Chronic
Microcirculation
Pentoxifylline*
Platelet Aggregation
Research Design
Creatinine
Pentoxifylline