Chonnam Med J.
2003 Sep;39(3):156-161.
Effects of Nitric Oxide on the Resting Activity of the Medial Vestibular Nuclear Neurons in the Rat
- Affiliations
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- 1Department of Physiology, Chonnam National University Medical School, Gwangju, Korea. parkjs@ jnu.ac.kr
- 2Department of Pharmacology, Chonnam National University Medical School, Gwangju, Korea.
- 3Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School, Gwangju, Korea.
- 4Chonnam National University Research Institute of Medical Sciences, Gwangju, Korea.
Abstract
- The aim of this study is to investigate the effects of nitric oxide on spontaneous activity of medial vestibular nuclear neurons of the rat by whole-cell patch clamp technique. Following results were obtained. The resting membrane potential of the medial vestibular nuclear neurons was increased by sodium nitroprussdie (SNP), a nitric oxide liberating agent. SNP did not affect the spike width, but decreased the depth of afterhyperpolarization of the action potential. SNP increased the firing rate of the medial vestibular nuclear neurons. These results suggest the nitric oxide increases the excitability of the neuron by altering the afterhyperpolarization.
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