Korean J Med.
2001 Jan;60(1):16-21.
Electron microscopic study of adhesion between Helicobacter pylori and gastric epithelial cell
- Affiliations
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- 1Department of Internal Medicine, Institute of Digestive Disease and Nutrition
- 2Department of Anatomy, Korea University College of Medicine
Abstract
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BACKGROUND: The purpose of this study was to investigate the ultrastructural relation of H. pylori and gastric epithelial cells in their adhesion.
METHODS
Endoscopic biopsy of gastric antrum and body was performed from 15 patients (9 men, 6 women) with chronic gastritis. These specimens were processed and observed by transmission electron microscope (Hitachi H-600).
RESULTS
On the basis of morphological appearances, the different types of adhesion of the organism with the epithelial cells were categorized as filamentous connection, adhesion pedestals, membrane fusion. Coccoid and intermediate forms were associated with filamentous connection whereas bacillary forms were associated with adhesion pedestals and membrane fusion.
CONCLUSION
Various types of adhesion were associated with H. pylori and gastric epithelium. Further studies are needed to investigate biophysiologic influence to epithelial cells by ultrastructural relationship.(Korean J Med 60:16-21, 2001)
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