J Korean Soc Ther Radiol Oncol.
1998 Mar;16(1):1-6.
Association of p53 Protein Expression with Clinical Outcome in Advanced Supraglottic Cancer
- Affiliations
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- 1Department of Radiation Oncology, College of Medicine Kyung Hee University Hospital, Seoul, Korea.
Abstract
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PURPOSE: To determine the incidence and prognostic effect of p53 expression in patients with advanced supraglottic cancer.
MATERIALS AND METHODS
Twenty-one cases of total 48 advanced supraglottic cancer patients who received postoperative adjuvant radiation therapy were evaluated by immunohistochemical staining employing p53 monoclonal antibody. RESULT: Three out of six stage III patients and four out of fifteen stage IV patients showed p53 expression without statistically significant difference (P=0.608). Five year survival rates are 93% in p53 negative, 86% in p53 positive patients and there was no significant difference (P=0.776). p53 expression does not show statistically significant correlation with primary tumor status (P=0.877), lymph node status (P=0.874) and age (P=0.64).
CONCLUSION
There was no statistically significant correlation between traditionally known risk factors and p53 expression.
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