Korean J Dermatol.  2000 Jun;38(6):789-792.

A Case of Buschke-Lowenstein Tumor That Progressed to Squamous Cell Carcinoma

• Kim TH
• Ahn HJ
• Choi EH
• Lee WS
• Hwang SM
• Ahn SK

Abstract

Buschke-Lowenstein (B-L) tumor occurs in penis associated with human papillomavirus (HPV). It appears as a exophytic cauliflower-like mass that may be foul smelling and sometimes ulcerated. B-L tumor is predominantly associated with HPV 6, 11 and rarely 16, 18. Because HPV 6, 11 are usually isolated from benign lesions, it has been hypothesized that other cofactors such as immunosuppression, poor hygiene, lack of circumcision, and chronic irritation may be involved. In addition, genomic alternation or subtle amino-acid changes in the HPV 6 E7 protein may play a role in enhancing oncogenic properties of the low-risk virus, HPV 6. We present a case of B-L tumor with squamous cell carcinoma that showed HPV 6 positive and altered p53.

Keyword

Buschke-Lowenstein tumor; Squamous cell carcinoma; HPV 6; p53

MeSH Terms

Buschke-Lowenstein Tumor*
Carcinoma, Squamous Cell*
Circumcision, Male
Female
Human papillomavirus 6
Humans
Hygiene
Immunosuppression
Male
Penis
Smell
Ulcer