J Korean Assoc Oral Maxillofac Surg.  2006 Jun;32(3):262-266.

The therapeutic effect of silver nanocrystalline ointment on TMJ capsulitis

  • 1Department of Dentistry, College of Medicine, Hallym University, Korea. epker@chollian.net
  • 2Chung Hoon Private Dental Clinic, Korea.
  • 3Department of Instrumental Analysis, KRIBB, Korea.
  • 4NPC Co., Ltd, Korea.
  • 5Korean Association for Temporomandibular Joint Corporation, Korea.


The silver nanocrystalline is widely used for biological field because of its biocompatibility and anti-microbial effect. The objective of this study was to evaluate the therapeutic efficacy of the silver nanocrystalline ointment on the temporomandibular joint (TMJ) capsulitis. Total 39 patients were included in this study and all patients were received single topical application of the silver nanocrystalline ointment (group A, n=30) or placebo ointment (group B, n=19). Measured variables were maximum mouth opening (MMO), visual analog scale (VAS) for pain, and VAS for function. In results, we could not assess any therapeutic efficacy of single application in the chronic TMJ capsulitis (p>0.05). However, the single application of silver nanocrystalline ointment showed significant improvement in MMO and VAS for pain compared to placebo effect in the acute TMJ capsulitis (p<0.05). We could not find any complications related to ointment application in both groups. In conclusion, the single application of silver nanocrystalline ointment was effective in improving patient's symptom in acute TMJ capsulitis without any noticing complications.

MeSH Terms

Placebo Effect
Temporomandibular Joint*
Visual Analog Scale
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