Korean J Dermatol.  1999 Mar;37(3):404-406.

A Case of Angioedema Probably Induced by Captopril

• Cho JJ
• Koh WS
• Kim BS

Abstract

Angioedema is a disorder characterized by well-demarcated nonpitting edema involving the tongue, floor of the mouth, larynx, lips, and face. The incidence of angiotensin converting enzyme(ACE) inhibitor related angioedema has been reported to be about 0.1% to 0.2%, and the time of onset is usually during the first week of therapy. These ACE inhibitors include captopril, enalapril, and lisinopril. A 53-year old man with an 8 month history of hypertension previously controlled with atenolol, was presented to the dermatologic department with angioedema of the face and tongue. He had begun therapy with captopril one day before this episode. Even though he was treated with epinephrine and methylprednisolone sodium succinate, the edema gradually progressed and finally dyspnea developed. He was urgently intubated and treated with steroids and pheniramine maleate in the intensive care unit. The edema resolved after 24 hours.

Keyword

Angioedema; Captopril

MeSH Terms

Angioedema*
Angiotensin-Converting Enzyme Inhibitors
Angiotensins
Atenolol
Captopril*
Dyspnea
Edema
Enalapril
Epinephrine
Humans
Hypertension
Incidence
Intensive Care Units
Larynx
Lip
Lisinopril
Methylprednisolone Hemisuccinate
Middle Aged
Mouth
Pheniramine
Steroids
Tongue
Angiotensin-Converting Enzyme Inhibitors
Angiotensins
Atenolol
Captopril
Enalapril
Epinephrine
Lisinopril
Methylprednisolone Hemisuccinate
Pheniramine
Steroids