J Korean Soc Emerg Med.  1997 Mar;8(1):98-102.

NEUROLEPTIC MALIGNANT SYNDROME-LIKE STATE DUE TO DEPOT OF CHLORPROMAZINE: A Case Report

Affiliations
  • 1Department of Emergency Medicine, Chonbuk National University Medicine School, Korea.

Abstract

The neuroleptic malignant syndrome(NMS) results primarily from an imbalance of central neurotransmitters and typically occurs after acute or chronic neuroleptic drug use rather than after neuroleptic overdosage. It is a rare and serious iatrogenic syndrome that is characterized by hyperthermia, muscle rigidity, autonomic dysfunctions and altered mental status. We have observed a case of NMS-like state due to depot of chlorpromazine(CPZ) and have experienced symptomatic and supportive treatment, which including body surface cooling, fluid administration, diuretics, and diazepam. So, in order to provide interests with this clinical situation for emergency physician, pathophysiology is discussed with references to the possibility of NMS in our case and symptomatology and managements are also reviewed.

Keyword

Hyperthermia; Chlorpromazine; Neuroleptic malignant syndrome

MeSH Terms

Chlorpromazine*
Diazepam
Diuretics
Emergencies
Fever
Muscle Rigidity
Neuroleptic Malignant Syndrome
Neurotransmitter Agents
Chlorpromazine
Diazepam
Diuretics
Neurotransmitter Agents
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