J Korean Soc Emerg Med.
1997 Mar;8(1):98-102.
NEUROLEPTIC MALIGNANT SYNDROME-LIKE STATE DUE TO DEPOT OF CHLORPROMAZINE: A Case Report
- Affiliations
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- 1Department of Emergency Medicine, Chonbuk National University Medicine School, Korea.
Abstract
- The neuroleptic malignant syndrome(NMS) results primarily from an imbalance of central neurotransmitters and typically occurs after acute or chronic neuroleptic drug use rather than after neuroleptic overdosage. It is a rare and serious iatrogenic syndrome that is characterized by hyperthermia, muscle rigidity, autonomic dysfunctions and altered mental status. We have observed a case of NMS-like state due to depot of chlorpromazine(CPZ) and have experienced symptomatic and supportive treatment, which including body surface cooling, fluid administration, diuretics, and diazepam. So, in order to provide interests with this clinical situation for emergency physician, pathophysiology is discussed with references to the possibility of NMS in our case and symptomatology and managements are also reviewed.
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