Infect Chemother.  2007 Oct;39(5):248-254.

Epidemiology of Candidemia in Neonates and Children: A Single Center Experience from 2001 to 2006

• Lee TJ
• Chun JK
• Kim DS

Abstract

PURPOSE: We evaluated epidemiological and clinical features of candidemia in neonates and children.
MATERIALS AND METHODS
We retrospectively reviewed the medical charts of hospitalized neonates and children with positive blood cultures for Candida species from September 1, 2000 through August 31, 2006.
RESULTS
Among 39 total neonates and children with candidemia, the median age was 4 months (interquartile range, 1-28) and overall mortality was 33%. Candida species included: Candida albicans (56%), Candida parapsilosis (23%) and Candida glabrata (15%). There was a tendency of proportional increase of candidemia due to non-albicans species (13% in 2001 vs 91% in 2006; P=0.01). Compared with children older than 1 month of age, the proportion of C. parapsilosis was significantly higher in neonates with candidemia (58% vs 7%; P=0.001). C. albicans was isolated more commonly from those who had undergone surgical intervention before candidemia (55% vs 18%; P<0.05). C. parapsilosis was isolated more commonly from premature neonates (78% vs 27%; P=0.015). C. glabrata was isolated more commonly from those who had neutropenia before candidemia (67% vs 12%; P=0.011).
CONCLUSION
Candidemia by C. albicans was more commonly in surgical patients; by C. parapsilosis in premature neonates; by C. glabrata in neutropenic patients.

Keyword

Candidemia; Invasive candidiasis; Fungal infections; Pediatric; Risk factors

MeSH Terms

Candida
Candida albicans
Candida glabrata
Candidemia*
Candidiasis, Invasive
Child*
Epidemiology*
Humans
Infant, Newborn*
Mortality
Neutropenia
Retrospective Studies
Risk Factors