Tuberc Respir Dis.  2007 Jan;62(1):51-55. 10.4046/trd.2007.62.1.51.

A Case of Bronchiolitis Obliterans Organizing Pneumonia from Epstein-Barr Virus

• Na HJ
• Kim SU
• Kim DH
• Nam DH
• Lee SM
• Kim CJ
• Kie JH
• Hong YK

• KMID: 1518489
• DOI: http://doi.org/10.4046/trd.2007.62.1.51

Abstract

In the average adult with a normal immune state, Epstein-Barr virus pneumonia is very rare, especially in the form of interstitial lung disease. According to recent studies, the Epstein-Barr virus is also associated with lymphocytic interstitial pneumonia, AIDS and Langerhans cell histiocytosis, but not with sarcoidosis. BOOP is caused by lung injury due to an infection or drug intoxication, and is related to connective tissue disease or bone marrow transplantation, but is sometimes idiopathic. We experienced a patient with symptoms and signs of interstitial lung disease, with confirmed BOOP and EBV ingection from an open lung biopsy and serologic examination, respectively Herein, this case is reported, with a review of the literature.

Keyword

Bronchiolitis obliterans organizing pneumonia; Epstein-barr virus

MeSH Terms

Adult
Biopsy
Bone Marrow Transplantation
Bronchiolitis Obliterans*
Bronchiolitis*
Connective Tissue Diseases
Cryptogenic Organizing Pneumonia*
Herpesvirus 4, Human*
Histiocytosis, Langerhans-Cell
Humans
Lung
Lung Diseases, Interstitial
Lung Injury
Pneumonia
Sarcoidosis

Figure

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  Figure 1 On H-E section, loose branching fibroblastic proliferations are observed within the terminal airway and alveolar spaces (A, H-E, ×200) with relatively mild interstitial inflammatory cell infiltration (B, H-E, ×400).

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  Figure 2 Chest radiograph shows diffuse ground glass opacity and reticular opacity in the both lungs (A). Chest PA after 5 months shows resolution of diffuse ground glass and reticular opacity in the both lungs (B).

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  Figure 3 Axial CT image shows diffuse patch distributed ground glass opacity and consolidation along the bronchovascular bundles (A). Three week follow-up Chest CT shows improvement of ground glass opacity and consolidation in the both lungs (B). Follow-up Chest CT after 1 year demonstrates resolution of diffuse pulmonary infiltration. Mild ground glass opacity and reticular opacity are remained (C).

Reference

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