Exp Neurobiol.  2011 Dec;20(4):189-196. 10.5607/en.2011.20.4.189.

Odor-Dependent Hemodynamic Responses Measured with NIRS in the Main Olfactory Bulb of Anesthetized Rats

• Lee HJ
• Nam Y
• Koh CS
• Im C
• Seo IS
• Choi S
• Shin HC

• KMID: 1495349
• DOI: http://doi.org/10.5607/en.2011.20.4.189

Abstract

In this study, we characterize the hemodynamic changes in the main olfactory bulb of anesthetized Sprague-Dawley (SD) rats with near-infrared spectroscopy (NIRS, ISS Imagent) during presentation of two different odorants. Odorants were presented for 10 seconds with clean air via an automatic odor stimulator. Odorants are: (i) plain air as a reference (Blank), (ii) 2-Heptanone (HEP), (iii) Isopropylbenzene (IB). Our results indicated that a plain air did not cause any change in the concentrations of oxygenated (Delta[HbO2]) and deoxygenated hemoglobin (Delta[Hbr]), but HEP and IB induced strong changes. Furthermore, these odor-specific changes had regional differences within the MOB. Our results suggest that NIRS technology might be a useful tool to identify of various odorants in a non-invasive manner using animals which has a superb olfactory system.

Keyword

near-infrared spectroscopy (NIRS); hemodynamic response; main olfactory bulb (MOB); non-invasive; odorant; brain-machine interface (BMI)

MeSH Terms

Animals
Benzene Derivatives
Hemodynamics
Hemoglobins
Ketones
Odors
Olfactory Bulb
Oxygen
Rats
Spectroscopy, Near-Infrared
Benzene Derivatives
Hemoglobins
Ketones
Oxygen