Clin Exp Reprod Med.
2013 Jun;40(2):90-94. 10.5653/cerm.2013.40.2.90.
The effectiveness of earlier oocyte retrieval in the case of a premature luteinizing hormone surge on hCG day in in vitro fertilization-embryo transfer cycles
- Affiliations
-
- 1Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Cheil General Hospital, Kwandong University College of Medicine, Seoul, Korea. ok58163@hanmail.net
- 2Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Bundang Cheil Women's Hospital, Seongnam, Korea.
- KMID: 1493215
- DOI: http://doi.org/10.5653/cerm.2013.40.2.90
Abstract
OBJECTIVE
To evaluate the efficacy of earlier oocyte retrieval in IVF patients with a premature LH surge on hCG day.
METHODS
One hundred forty IVF patients (164 cycles) with premature LH surge on hCG day were included, retrospectively. We divided them into 2 study groups: LH surge with timed ovum pick-up (OPU) 36 hours after hCG injection (group B, 129 premature cycles), and LH surge with earlier OPU within 36 hours after hCG injection (group C, 35 cycles). Control groups were tubal factor infertility without premature LH surge (group A, 143 cycles).
RESULTS
The mean age (year) was statistically higher in group C than in groups A or B (38.2+/-5.4 vs. 36.2+/-4.2 vs. 36.8+/-4.9, respectively; p=0.012). The serum LH levels (mIU/mL) on hCG day were significantly higher in group B and C than in group A (22.7+/-14.9 vs. 30.3+/-15.9 vs. 3.2+/-2.9, respectively; p>0.001). Among groups A, B, and C, 4.9%, 31.7%, and 51.4% of the cycles, respectively, had no oocytes, and the overall rates of cycle cancellation (OPU cancellation, no oocyte, or no embryos transferrable) were 15.4%, 65.9%, and 74.3%, respectively. The fertilization rate (%) was significantly higher in group B than in group C (73.2+/-38.9 vs. 47.8+/-42.9, p=0.024). The clinical pregnancy rate was significantly higher in group C than in groups A and B (44.4% vs. 27.3% vs. 9.1%, respectively, p=0.021). However, the miscarriage rate was also higher in group C than in group B (22% vs. 0%, respectively, p=0.026).
CONCLUSION
Earlier OPU may not be effective in reducing the risk of cycle cancellation in patients with premature LH surge on hCG day. A larger scale study will be required to reveal the effectiveness of earlier ovum retrieval with premature LH surge.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Effect of Sequential Embryo Transfer in vitro Fertilization
- A Case of Empty Follicle Syndrome with Successful Oocyte Retrieval by Use of Recombinant Human Chorionic Gonadotropin
- Clinical Efficacy and Hormonal Change of GnRH Antagonist in Controlled Ovarian Stimulation for IVF-ET
- Day 3 Trasfer Program in In Vitro Fertilization and Embryo Transfer
- Clinical Significance of CA-125 and Insulin-like Growth Factor Binding Protein-3 ( IGFBP-3 ) as a Prognostic Factor for Pregnancy Outcome in In Vitro Fertilization and Embryo Transfer
