Clin Exp Otorhinolaryngol.  2012 Dec;5(4):237-239. 10.3342/ceo.2012.5.4.237.

Primary Osteosarcoma Arising from the Middle Turbinate in a Pediatric Patient

• Kim YJ
• Kim YJ
• Chu YC
• Lee JW
• Jeon YS
• Lee KH
• Cho SG
• Kim MY

• KMID: 1489086
• DOI: http://doi.org/10.3342/ceo.2012.5.4.237

Abstract

Osteosarcomas usually occur as secondary tumors after radiation therapy or chemotherapy. Without a history of irradiation to the head and neck area, primary osteosarcoma of the turbinate is extremely rare. We report here a rare case of primary turbinate osteosarcoma presenting as a relatively small, well-circumscribed, turbinate mass. Its appearance mimicked a benign nasal mass like mucocele and polyp. We also reviewed the previously reported cases of tumor arising from turbinate.

Keyword

Osteosarcoma; Turbinate; Primary

MeSH Terms

Head
Humans
Mucocele
Neck
Osteosarcoma
Polyps
Turbinates

Figure

• 

  Fig. 1 Primary osteosarcoma arising from middle turbinate in a 9-year-old girl. (A) A non-contrast, coronal computed tomography scan showed a well defined, hyperattenuating mass with loss of turbinate detail. The mass showed intermediate signal intensity on a sagittal T1-weighted image (B) and low signal intensity on an axial T2-weighted image (C) and was enhanced on postcontrast image (D). (E) A photomicrograph (×400) showed the presence of hyperchromatic spindle cells with a disorganized maze of calcified tissue including osteoid.

Reference

1. Garrington GE, Scofield HH, Cornyn J, Hooker SP. Osteosarcoma of the jaws. Analysis of 56 cases. Cancer. 1967; 3. 20(3):377–391. PMID: 5228026.

2. Maes P, Brichard B, Vermylen C, Cornu G, Ninane J. Primary and secondary osteosarcoma of the face: a rare childhood malignancy. Med Pediatr Oncol. 1998; 3. 30(3):170–174. PMID: 9434826.

3. Jin HR, Lee OJ, Ahn Y. Nasal cavity paraganglioma with malignant transformation: a case report. Auris Nasus Larynx. 2008; 3. 35(1):137–139. PMID: 17889472.

4. Chen KT, Weinberg RA, Simpson PR, Tschang TP. Osteoblastoma of the nasal cavity. J Laryngol Otol. 1993; 8. 107(8):737–739. PMID: 8409731.

5. Fahmy FF, Back G, Smith CE, Hosni A. Osseous haemangioma of inferior turbinate. J Laryngol Otol. 2001; 5. 115(5):417–418. PMID: 11410139.

6. Unlu HH, Celik O, Demir MA, Eskiizmir G. Pleomorphic adenoma originated from the inferior nasal turbinate. Auris Nasus Larynx. 2003; 12. 30(4):417–420. PMID: 14656569.

7. Saetti R, Silvestrini M, Marino F, Narne S. Fibrous dysplasia of middle turbinate associated with Widal syndrome: endoscopic treatment of a rare case. Acta Otorhinolaryngol Ital. 2004; 10. 24(5):288–291. PMID: 15871611.

8. Nomura K, Shimomura A, Awataguchi T, Murakami K, Kobayashi T. A case of angiofibroma originating from the inferior nasal turbinate. Auris Nasus Larynx. 2006; 6. 33(2):191–193. PMID: 16310998.

9. Iseri M, Ozturk M, Filinte D, Corapcloglu F. A peripheral primitive neuroectodermal tumor arising from the middle turbinate and transnasal endoscopic approach for its surgical treatment. Int J Pediatr Otorhinolaryngol Extra. 2007; 9. 2(3):180–184.

10. Akman K, Aydin E, Ozen O, Ozluglu LN. Lobular capillary hemangioma of the middle turbinate. Turk Arch Otolaryngol. 2007; 45:48–51.

11. Lee JY, Jang YD, Kim HK. The primary role of the otolaryngologist in managing pediatric sinonasal malignancies: an extranodal NK/T-cell lymphoma originating from the inferior turbinate mucosa of the nasal cavity. J Pediatr Hematol Oncol. 2008; 5. 30(5):401–404. PMID: 18458579.

12. Ishimaru T. Superior turbinate osteoma: a case report. Auris Nasus Larynx. 2005; 9. 32(3):291–293. PMID: 15869855.

13. Zinreich SJ, Kennedy DW, Malat J, Curtin HD, Epstein JI, Huff LC, et al. Fungal sinusitis: diagnosis with CT and MR imaging. Radiology. 1988; 11. 169(2):439–444. PMID: 3174990.

14. Rao VM, el-Noueam KI. Sinonasal imaging. Anatomy and pathology. Radiol Clin North Am. 1998; 9. 36(5):921–939. PMID: 9747194.