Korean J Nephrol.  2008 Nov;27(6):666-677.

An Analysis of 3,000 Cases of Percutaneous Renal Biopsy: Single Center Study

• Chang MH
• Hwang EA
• Kim JE
• Yoon JS
• Park WY
• Kang SS
• Han SY
• Park SB
• Kim HC
• Choe MS

Abstract

PURPOSE: The incidence of glomerular diseases varies according to population characteristics and time period.
METHODS
A total of 3,000 renal biopsies were performed over the 29 years' period from 1978 to 2007. We reviewed the patient records of all patients who underwent renal biopsies at our institution. The patients were grouped for analysis in three time intervals: before 1990, 1991 to 2000, and after 2001.
RESULTS
There were 2,377 cases of native kidney biopsies and 623 cases of allograft kidneys. The principal long-term changes were an increase in the mean age of patients with undergoing biopsy and an increase in the percentage of asymptomatic urinary abnormalities as an indication for biopsy. In the primary glomerulonephritis (GN), the most common pathologic diagnosis was IgA nephropathy (IgAN, 26.6%), followed by minimal change disease (MCD, 21.4%), membranous nephropathy (8.9%), focal segmental glomerulosclerosis (7.7%). The major changes noted in primary GN were a marked increase in the frequency of IgAN and decrease in the frequency of MCD. Major causes of secondary GN were lupus nephritis (37.9%), and hepatitis associated GN (28.9%). In allograft biopsies, acute rejection (42.3%) and chronic rejection (19.4%) were the two most common diagnoses. Documented complications of renal biopsies included perirenal hematoma (25.1%), but the rate of serious complications that required surgical intervention or embolization was very low (1.0%). There was no death or nephrectomy case in our study.
CONCLUSION
IgAN was the most common primary GN in this study. The multi-center studies are needed to evaluate the distribution and changing trends of renal disease in Korea.

Keyword

Renal biopsy; Glomerular disease; Complication

MeSH Terms

Biopsy
Corneal Dystrophies, Hereditary
Glomerulonephritis
Glomerulonephritis, IGA
Glomerulonephritis, Membranous
Glomerulosclerosis, Focal Segmental
Hematoma
Hepatitis
Humans
Incidence
Kidney
Lupus Nephritis
Nephrectomy
Nephrosis, Lipoid
Population Characteristics
Rejection (Psychology)
Transplantation, Homologous
Corneal Dystrophies, Hereditary
Glomerulosclerosis, Focal Segmental