Korean J Obstet Gynecol.  2009 Mar;52(3):372-376.

A case of microinvasive Paget's disease of the vulva: Treatment of positive resection margin with topical 5-FU cream application

Affiliations
  • 1Department of Obstetrics and Gynecology, Cheju National University, College of Medicine, Jeju, Korea. kimsy@cheju.ac.kr

Abstract

Extramammary Paget's disease of the vulva is a rare lesion that accounts for 1~2% of vulvar neoplasms. Paget's disease often has a microscopic extension beyond the gross lesion and shows a multifocal distribution. Positive resection margin is common. We applied 5-FU cream on the lesion who had a positive resection margin. There was no residual lesion on multiple punch biopsies after 5-FU cream treatment three months later. And there has been no evidence of disease recurrence in the 12-month follow-up period. We experienced a case of effective treatment with 5-FU cream in microinvasive Paget's disease of the vulva with positive resection margin. We present it with a brief review of literatures.

Keyword

Extramammary Paget's disease of the vulva; 5-fluorouracil (5-FU)

MeSH Terms

Biopsy
Fluorouracil
Follow-Up Studies
Recurrence
Vulva
Vulvar Neoplasms
Fluorouracil
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