J Korean Med Assoc.  2009 Feb;52(2):191-198. 10.5124/jkma.2009.52.2.191.

New Medical Drugs for Care of Premature Infants

Affiliations
  • 1Department of Pediatrics, Kyunghee University College of Medicine, Korea. baecw@khnmc.or.kr

Abstract

Several advances in premature and neonatal care, such as, development in new drugs and equipments, and improvement of medical skills, have also undoubtedly contributed to the reductions in morbidity and mortality of premature infants during last several decades in Korea. This review was conducted for focusing the development of new medical drug therapy and its clinical application and outcomes for preterm. The details of the artificial pulmonary surfactant replacement therapy for respiratory distress syndrome, indomethacin for patent ductus arteriosus, inhaled nitric oxide therapy for persistent pulmonary hypertension, total parenteral nutrition, and drugs for neonatal resuscitation program were reviewed in this paper.

Keyword

Medical drug; Therapy; Preterm; Prematurity; Newborn

MeSH Terms

Ductus Arteriosus, Patent
Humans
Hypertension, Pulmonary
Indomethacin
Infant, Newborn
Infant, Premature
Korea
Nitric Oxide
Parenteral Nutrition, Total
Pulmonary Surfactants
Resuscitation
Indomethacin
Nitric Oxide
Pulmonary Surfactants

Figure

  • Figure 1 Changes in respiratory distress syndrome mortality rates over the past 17years among those that received pulmonary surfactant replacement therapy in Korea. Mortality rates were found to have reduced dramatically, that is, from 40%, 30%, 18.7%, to 14.3% in Groups I (1990/1), II (1996), III (2002), and IV (2007), respectively.

  • Figure 2 Changes of mortality in 5-yr interval of low birth weight infant (LBWI) and very low birth weight infant (VLBWI) in Korea. (A) first half of the decade, (B) second half of the decade.

  • Figure 3 Trends in the survival rates for very low birth weight infants (VLBWI) and extremely low birth weight infants (ELBWI) in Korea. (A) first half of the decade, (B) second half of the decade.


Reference

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